Evidence map›Paper›PMID 42845659›Full record

ArticleResearch square2026

High-frequency oscillations arise through distinct mechanisms in models of α- synucleinopathy and channelopathy-induced epilepsy.

Rahil N Vaknalli, Kwaku Addo-Osafo, Vishnu Shandilya M C, Kaylin Hwang, Mariane Vicente, Anatol Bragin, Keith Vossel

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PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Rahil N VaknalliDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Kwaku Addo-OsafoDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Vishnu Shandilya M CDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Kaylin HwangDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Mariane VicenteDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Anatol BraginDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.
Keith VosselDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States.

Funding

Astrocyte and neuron brain-region and compartment-specific proteome dynamics in aging and Alzheimer’s diseaseR01AG075955 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KHAKH, BALJIT, VOSSEL, KEITH ALAN · 2021 to 2025
$5.2M
In Vivo Studies of the Epileptic HippocampusRF1NS033310 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ENGEL, JEROME NONE, STABA, RICHARD · 2023 to 2023
$3.6M
Leveraging the Electronic Health Record and Integrating Social and Biological Data to Expand Dementia Research in Understudied Populations in Los Angeles CountyUH3AG083254 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Keith Alan Vossel · 2025 to 2026
$2.3M
Preventing Seizures and Associated Memory Loss in Alzheimer's Disease by Blocking Tau Interactions with SH3-containing Proteins.R01AG058820 · NIA · UNIVERSITY OF MINNESOTA · PI VOSSEL, KEITH ALAN · 2019 to 2023
$1.9M
Alpha-Synuclein Induced Network Hyperexcitability in Lewy Body DementiasR56AG074473 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEE, MICHAEL K, MOORE, DARREN JOHN · 2021 to 2021
$840k
NIA NIH HHS R01 AG058820NIA NIH HHS R01 AG075955NIA NIH HHS R56 AG074473NIA NIH HHS UH3 AG083254NINDS NIH HHS RF1 NS033310
6 · The paper itself

Abstract

Background: Pathological high-frequency oscillations (HFOs), widely researched in epilepsy, are increasingly being investigated as potential biomarkers of network hyperexcitability in neurodegenerative disorders. This interest is driven by growing evidence of comorbidity between epilepsy and neurodegenerative diseases, particularly Alzheimer's disease (AD) and dementia with Lewy bodies (DLB), suggesting that these HFOs could be useful biomarkers in these disorders. Patients with AD and mouse models of AD exhibit elevated HFOs during neurophysiology recordings, but whether HFOs occur in DLB remains unknown. Methods: To address this question, we quantified cortical HFOs within the spectral range of 250-500 Hz and interictal spikes using surface electroencephalography recordings in a transgenic model of α-synucleinopathy that exhibits features of DLB (A53T mice) and a model of channelopathy-induced epilepsy ( Results: Both A53T and Conclusions: Our findings indicate that HFOs likely arise from different neuronal populations and are generated through distinct mechanisms in these two models. Importantly, this work shows that HFOs are an electroencephalographic abnormality in a model of DLB and supports their potential as a new biomarker for neurodegenerative disorders.

Indexed as

Alzheimer’s diseaseBiomarkerDementia with Lewy BodiesEpilepsyHigh-frequency oscillationsHyperactivity

Identifiers

PMID42845659
PMCPMC13640886

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.