ArticleResearch square2026
A novel multisystem approach uncovers conserved mitochondrial complex I disease phenotypes and suppressors.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Mitochondriopathies are a large group of pathological conditions characterized by dysfunction of tissues and organs with high energy needs such as the brain, heart, and skeletal muscles, which highly rely on functional mitochondrial oxidative phosphorylation (OXPHOS). The vast majority of these disorders are ascribed to mutations in nuclear or mitochondrial encoded subunits of complex I (CI), the largest OXPHOS complex. In this study, we develop a multisystemic pipeline for CI-associated disease based on new approach methods (NAMs), which includes non-mammalian models, namely
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