Evidence map›Paper›PMID 42845518›Full record

ArticlebioRxiv : the preprint server for biology2026

Outside-in progression of heterochromatin replication and exclusion of CDC45 from the PCH domain in

Collin Hickmann, Srigokul Upadhyayula, Gary H Karpen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Collin HickmannDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0009-0001-8587-0448
Srigokul UpadhyayulaDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0001-6727-5883
Gary H KarpenDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA, USA.ORCID 0000-0003-1534-0385

Funding

GENOMICST32HG000047 · NHGRI · UNIVERSITY OF CALIFORNIA BERKELEY · PI RASMUS NIELSEN, Daniel Soleyman Rokhsar · 2000 to 2026
$13.5M
Genetic Dissection of Cells and Organisms Training ProgramT32GM132022 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Nicole King, NOAH K WHITEMAN · 2019 to 2026
$5.2M
Interplay Between Nuclear Organization and FunctionR35GM139653 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI KARPEN, GARY H · 2021 to 2025
$4.4M
Organization and Function of the Heterochromatin Holodomain and SubdomainsR01GM117420 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI KARPEN, GARY H · 2016 to 2019
$2.5M
NHGRI NIH HHS T32 HG000047NIGMS NIH HHS R01 GM117420NIGMS NIH HHS R35 GM139653NIGMS NIH HHS T32 GM132022
6 · The paper itself

Abstract

Heterochromatin replication isn't random or uniform, but occurs in a characteristic spatial and temporal pattern. Previous studies produced conflicting models for pericentric heterochromatin (PCH) replication, suggesting either that heterochromatic sequences translocate to the domain surface for replication, or that replication can also occur internally through localized decondensation. To distinguish true overlap from peripheral enrichment around an irregular PCH domain, we developed FOC-Map, a colocalization analysis approach that combines segmentation of one channel with binning of the other. Applying FOC-Map to three-dimensional Airyscan imaging of cultured

Identifiers

PMID42845518
PMCPMC13640786

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.