Evidence map›Paper›PMID 42845479›Full record

ArticlebioRxiv : the preprint server for biology2026

Geroprotective drug discovery with an AI-enabled assay for heat resistance.

Thomas J Hodder, Allancer D C Nunes, Bryan A Martinez, Karla J Opperman, Paul D Robbins, Chad L Myers, Matthew S Gill

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Thomas J HodderMasonic Institute on the Biology of Aging & Metabolism, University of Minnesota.ORCID 0009-0000-3060-572X
Allancer D C NunesMasonic Institute on the Biology of Aging & Metabolism, University of Minnesota.ORCID 0000-0003-4158-683X
Bryan A MartinezMasonic Institute on the Biology of Aging & Metabolism, University of Minnesota.ORCID 0000-0002-0133-0306
Karla J OppermanMasonic Institute on the Biology of Aging & Metabolism, University of Minnesota.ORCID 0000-0001-9545-8361
Paul D RobbinsMasonic Institute on the Biology of Aging & Metabolism, University of Minnesota.ORCID 0000-0003-1068-7099
Chad L MyersDepartment of Computer Science & Engineering, University of Minnesota.ORCID 0000-0002-1026-5972
Matthew S GillMasonic Institute on the Biology of Aging & Metabolism, University of Minnesota.ORCID 0000-0003-0818-8792

Funding

Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla · 2019 to 2026
$28.7M
Midwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5M
Minnesota Tissue Mapping Center for Senescent CellsU54AG076041 · NIA · UNIVERSITY OF MINNESOTA · PI Constantin F. Aliferis, LAURA Jane NIEDERNHOFER · 2021 to 2026
$10.5M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Training Grant: Functional Proteomics of AgingT32AG029796 · NIA · UNIVERSITY OF MINNESOTA · PI EDGAR A ARRIAGA, Douglas G Mashek · 2008 to 2026
$6.6M
NIA NIH HHS P01 AG062413NIA NIH HHS T32 AG029796NIA NIH HHS U54 AG076041NIA NIH HHS U54 AG079754NIH HHS P40 OD010440
6 · The paper itself

Abstract

Drugs that slow the rate of organismal aging (geroprotectors) have the potential to improve human healthspan by preventing the development of multiple chronic diseases. The nematode

Identifiers

PMID42845479
PMCPMC13640661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.