ArticlebioRxiv : the preprint server for biology2026
Activity-dependent homeostatic synaptic plasticity widens the temperature range of synaptic transmission.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
The framework of homeostatic plasticity posits that neurons regulate cellular properties through feedback homeostasis to maintain activity during changes in the environment. However, when disturbances occur in wild animals they are often caused by environmental variables that induce their own acclimation effects, making it difficult to discern if activity-sensitive feedback plays a role in ecological settings. We addressed this problem using a natural activity perturbation, where frogs hibernate in cold water, leaving brainstem motor circuits that generate breathing inactive for long periods. We show here that motor inactivity, amid complex environmental variables in the hibernation environment, represents a key signal for increasing AMPA-glutamate receptors (AMPARs) on motoneurons. Homeostatic upregulation of AMPARs do not regulate neural activity
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