Evidence map›Paper›PMID 42845398›Full record

ArticlebioRxiv : the preprint server for biology2026

Chemokine Landscapes of the Tumor Microenvironment.

Lukas M Altenburger, Aditya Patil, Jakob Jobst, Raphael Kfuri-Rubens, Taylor T Chrisikos, Kazuiro Taguchi, Meredith F Ellis, Nicolas Röhrle, Murat Tekguc, Zhijian Li and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lukas M AltenburgerCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-7998-5484
Aditya PatilCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.
Jakob JobstCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.
Raphael Kfuri-RubensInstitute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.ORCID 0000-0003-3256-9640
Taylor T ChrisikosCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-8966-4046
Kazuiro TaguchiCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0003-1049-4203
Meredith F EllisCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0009-0003-5018-3108
Nicolas RöhrleCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.
Murat TekgucHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0001-7570-5898
Zhijian LiHarvard Medical School, Boston, MA 02115, USA.
Ryuji MorizaneHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-0377-5667
Luca PinelloHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0003-1109-3823
Fabian TheisInstitute of Computational Biology, Helmholtz Munich, Neuherberg, Germany.ORCID 0000-0002-2419-1943
Andrew D LusterCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-9679-7912
Orr AshenbergBroad Institute of MIT and Harvard, Cambridge, MA 02142, USA.ORCID 0000-0002-7802-8834
Ramnik J XavierHarvard Medical School, Boston, MA 02115, USA.ORCID 0000-0002-5630-5167
Lloyd BodCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-8124-0863
Rod A RahimiCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-7929-2899
Gary ReynoldsCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0002-8142-8708
Thorsten R MempelCenter for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, MA 02129, USA.ORCID 0000-0001-8635-5424

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokines are well-recognized for orchestrating immune cell traffic between tissues via the blood and lymph, yet how they guide the formation of cellular neighborhoods and niches within inflamed tissues remains largely unknown. Here, we use spatial transcriptomics to comprehensively map the chemokine landscape in the chronic inflammatory environment of solid tumors. In murine models representing melanoma, sarcoma, and carcinoma, we identify conserved and tumor type-specific patterns for individual chemokines, including exclusive or preferential expression in tumor core versus stroma and distinct microdomains of different size and boundary sharpness within those compartments. We further identify perivascular CCR7

Indexed as

CCR7+ dendritic cellscell-cell communicationcellular interactionscellular neighborhoodsChemokinesinflammationspatial transcriptomicstissue nichestumor microenvironment

Identifiers

PMID42845398
PMCPMC13640662

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.