Evidence map›Paper›PMID 42845378›Full record

ArticlebioRxiv : the preprint server for biology2026

A NON-CANONICAL ROLE FOR NOTCH3 IN BUILDING THE INTESTINAL LYMPHATIC NICHE.

Liqing Huang, Bhargav Sanketi, Madhav Mantri, Yanxi Chen, Clare Wang, Tristan Tran, Iwijn De Vlaminck, Natasza A Kurpios

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liqing HuangDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0000-0003-3894-6646
Bhargav SanketiDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0000-0002-0581-7509
Madhav MantriDepartment of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0001-9844-7852
Yanxi ChenDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0009-0008-5779-1903
Clare WangDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0009-0004-7139-2299
Tristan TranDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0009-0001-4441-9423
Iwijn De VlaminckDepartment of Biomedical Engineering, Cornell University, Ithaca, NY 14850, USA.ORCID 0000-0001-6085-7311
Natasza A KurpiosDepartment of Biomedical and Translational Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.ORCID 0000-0002-1251-7395

Funding

Mechanisms underlying form and function of the contractile gut lymphaticsR01DK092776 · NIDDK · CORNELL UNIVERSITY · PI Natasza A Kurpios · 2012 to 2026
$5.6M
Precision monitoring of kidney transplants via single-cell and single-molecule sequencingDP2AI138242 · NIAID · CORNELL UNIVERSITY · PI DE VLAMINCK, IWIJN · 2017 to 2017
$2.3M
Morphogenetic mechanisms of intestinal lymphatic smooth muscle-lacteal complex function and dysfunctionR56DK139238 · NIDDK · CORNELL UNIVERSITY · PI KURPIOS, NATASZA A · 2024 to 2024
$644k
Zeiss LSM710 Confocal Microscope for Shared Imaging FacilityS10RR025502 · NCRR · CORNELL UNIVERSITY · PI WILLIAMS, REBECCA M · 2009 to 2009
$500k
NCRR NIH HHS S10 RR025502NIAID NIH HHS DP2 AI138242NIDDK NIH HHS R01 DK092776NIDDK NIH HHS R56 DK139238
6 · The paper itself

Abstract

Lymphatic dysfunction drives severe and often intractable human diseases, yet the cellular mechanisms that establish functional lymphatic vasculature remain poorly understood. In the intestine, lacteals are specialized lymphatic vessels that absorb dietary lipids and rely on surrounding villus smooth muscle to propel lymph, forming the muscular-lacteal complex (MLC). How distinct mesenchymal populations coordinate assembly of this functional lymphatic unit remains unknown. By integrating developmental single-cell profiling, genetic lineage tracing, conditional mouse genetics, and functional assays of lipid absorption, we identify Notch3 as a central organizer of MLC development that coordinates communication between distinct mesenchymal lineages. While Notch3 promotes smooth muscle differentiation within the PDGFRα

Identifiers

PMID42845378
PMCPMC13640725

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.