Evidence map›Paper›PMID 42845376›Full record

ArticlebioRxiv : the preprint server for biology2026

A Mechanical Theory for the Formation of Short Association Fibers in the Brain.

Akbar Solhtalab, Jixin Hou, Guannan Cao, Zhibin He, Lana Pierotich, Tuo Zhang, Kara E Garcia, Xianqiao Wang, Mir Jalil Razavi

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Akbar SolhtalabDepartment of Mechanical Engineering, State University of New York at Binghamton, Binghamton, NY 13902, USA.ORCID 0009-0006-4766-3727
Jixin HouSchool of Environmental, Civil, Agricultural and Mechanical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
Guannan CaoSchool of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China.
Zhibin HeSchool of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China.
Lana PierotichDivision of Newborn Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Tuo ZhangSchool of Automation, Northwestern Polytechnical University, Xi'an, Shaanxi 710072, China.
Kara E GarciaDepartment of Radiology and Imaging Sciences, Indiana University School of Medicine, Evansville, IN 47715, USA.
Xianqiao WangSchool of Environmental, Civil, Agricultural and Mechanical Engineering, College of Engineering, University of Georgia, Athens, GA 30602, USA.
Mir Jalil RazaviDepartment of Mechanical Engineering, State University of New York at Binghamton, Binghamton, NY 13902, USA.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Mechanics of Brain Folding in Human Infants Evaluated Using MRIR01NS133116 · NINDS · INDIANA UNIVERSITY INDIANAPOLIS · PI Kara E Garcia · 2024 to 2026
$1.6M
SCH: Using Data-Driven Computational Biomechanics to Disentangle Brain Structural Commonality, Variability, and Abnormality in ASDR01NS135574 · NINDS · UNIVERSITY OF GEORGIA · PI Xianqiao Wang · 2023 to 2026
$1.1M
NIMH NIH HHS U54 MH091657NINDS NIH HHS R01 NS133116NINDS NIH HHS R01 NS135574
6 · The paper itself

Abstract

The development of neural connections in the brain results from a complex interplay between biological processes and mechanical forces. A key question in neuroscience is how physical forces and the mechanical properties of brain tissue influence the formation of structural connections. Here, we demonstrate that mechanical forces play an essential role in shaping the emergence of short-range connections, particularly U-shaped fibers that link neighboring regions of the cortex. Using a computational model that incorporates our "stress-dependent axon reorientation" hypothesis, we simulate how growing axons respond to the mechanical stress field generated by cortical folding. Our results suggest that axonal growth and reorientation may be strongly influenced by local mechanical cues, helping establish the organization of these short-range pathways. Supported by

Indexed as

Axon ReorientationCortical FoldingMechanicsShort Association Fibers

Identifiers

PMID42845376
PMCPMC13640728

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.