Evidence map›Paper›PMID 42845353›Full record

ArticlebioRxiv : the preprint server for biology2026

Antioxidant modulation of stress behavior depends on stress coping style: a role for N-acetylcysteine amide.

Ryan Y Wong, Brooklynn K Schmidt, Cherylynn R Gibson, Peter D Dijkstra

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Ryan Y WongUniversity of Nebraska at Omaha, Department of Biology, Omaha, NE USA.ORCID 0000-0003-0236-672X
Brooklynn K SchmidtUniversity of Nebraska at Omaha, Department of Psychology, Omaha, NE USA.
Cherylynn R GibsonUniversity of Nebraska at Omaha, Department of Biology, Omaha, NE USA.
Peter D DijkstraCentral Michigan University Biology Department, Mount Pleasant, MI USA.ORCID 0000-0001-5382-225X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Animals experience stressors in a variety of contexts that result in activation of neuroendocrine and cellular stress responses. Release of stress hormones can disrupt or restore redox homeostasis, and the resulting changes in oxidative states, physiology and behavior vary by an individual's stress coping style. However, oxidative stress can also directly modulate neuroendocrine stress signaling. To what extent individual differences in brain antioxidant levels alter behavioral stress levels is not well understood. The present study investigated how

Indexed as

antioxidantN-acetylcysteine amideoxidative stressstressstress coping style

Identifiers

PMID42845353
PMCPMC13640674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.