Evidence map›Paper›PMID 42845343›Full record

ArticlebioRxiv : the preprint server for biology2026

Kate M Van Pelt, Yamei Deng, Alexey I Nesvizhskii, Henry L Paulson, Maria do Carmo Costa, Matthias C Truttmann

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kate M Van PeltProgram in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0001-6892-9658
Yamei DengDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Alexey I NesvizhskiiDepartment of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-2806-7819
Henry L PaulsonDepartment of Neurology, 109 Zina Pitcher Place, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-0382-7535
Maria do Carmo CostaDepartment of Pharmacology and Toxicology, College of Human Medicine, Michigan State University, East Lansing, MI, 48824, USA.ORCID 0000-0001-8466-4864
Matthias C TruttmannDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.ORCID 0000-0002-0536-7923

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinocerebellar ataxia type 3 (SCA3) is an inherited, fatal neurodegenerative disease caused by a pathological CAG repeat expansion in the ATXN3 gene, resulting in the selective degeneration of vulnerable neuronal populations. Recent work has identified impairments in oligodendrocyte maturation as a novel and robust feature of SCA3 pathogenesis. Oligodendrocytes synthesize myelin structural components through the endoplasmic reticulum (ER), rendering this organelle essential for white matter integrity. Despite this, the role of ER function in SCA3 remains unclear. In this study, we show that loss of FICD-mediated AMPylation, a post-translational modification regulating the ER-resident HSP70 chaperone, BiP, rescues motor impairments in a transgenic SCA3 mouse model.

Identifiers

PMID42845343
PMCPMC13640601

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.