Evidence map›Paper›PMID 42845321›Full record

ArticleWellcome open research2025

Living Rapid Research Needs Appraisal (RRNA) for Priority Diseases Protocol.

Marieke de Swart, Dijana Spasenoska, Eli Harriss, Vincent Cheng, Katrin Probyn, Gemma Villanueva, Thomas Mendy, Musawenkosi Ndlovu, Brian Buckley, Daniela Toale and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Wellcome open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marieke de SwartPolicy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, England, UK.
Dijana SpasenoskaPolicy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, England, UK.ORCID https://orcid.org/0000-0003-3640-4405
Eli HarrissHealth Care Libraries, University of Oxford Bodleian Libraries, Oxford, England, UK.
Vincent ChengUniversity of Bristol Medical School, Bristol, England, UK.
Katrin ProbynCochrane Response, Cochrane, London, England, UK.
Gemma VillanuevaCochrane Response, Cochrane, London, England, UK.
Thomas MendyPolicy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, England, UK.ORCID https://orcid.org/0009-0003-1132-3307
Musawenkosi NdlovuCochrane South Africa, Tygerberg, Cape Town, South Africa.ORCID https://orcid.org/0000-0002-5901-6766
Brian BuckleyCochrane Response, Cochrane, London, England, UK.
Daniela ToalePolicy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, England, UK.
Nicholas HenschkeCochrane Response, Cochrane, London, England, UK.
Duduzile NdwandweCochrane South Africa, Tygerberg, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-7129-3865
Alice NortonPolicy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, England, UK.ORCID https://orcid.org/0000-0001-8908-2775
Louise SigfridPolicy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, England, UK.ORCID https://orcid.org/0000-0003-2764-1177

Funding

Wellcome Trust
6 · The paper itself

Abstract

Systematic reviews require time and resources to conduct that might not be available in a rapidly developing context such as during new and (re-) emerging infectious disease outbreaks. As part of the Pandemic-PACT program at the Pandemic Sciences Institute at the University of Oxford we have, in collaboration with Cochrane Response and Cochrane South Africa, developed a "living" Rapid Research Needs Appraisal (RRNA) methodology. The aim is to develop a protocol for rapidly and robustly identify key evidence gaps across pre-defined research domains to inform research prioritisation and coordination in preparedness time and during outbreaks. The RRNA utilises modified systematic review methods, a global relay of reviewers, and systematic review software. The objective is to strengthen capability for carrying out RRNAs, and establish a baseline evidence platform for priority infectious diseases that can be readily updated as new evidence emerges, utilising an adaptable "living" RRNA protocol. This data will be of relevance to funders, researchers, clinical and public health stakeholders involved in management of infectious diseases of epidemic and pandemic potential.

Indexed as

Priority Diseases: Emerging Infections: Rapid Research Needs Appraisal: Evidence Gaps: Research Prioritisation

Identifiers

PMID42845321
PMCPMC13639346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.