Evidence map›Paper›PMID 42845296›Full record

ArticlebioRxiv : the preprint server for biology2026

Trex-QTL: A mixture-model for identification of genetic effects with global effects on molecular phenotypes.

Cynthia Wu, Andrey Bzikadze, Tianyao Xu, Eric M Mendenhall, Hao Chen, Francesca Telese, Oksana Polesskaya, Daniel Munro, Abraham A Palmer, Alon Goren and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cynthia WuBioinformatics and Systems Biology Program, UC San Diego, La Jolla, CA, USA.ORCID 0000-0002-3687-2199
Andrey BzikadzeBioinformatics and Systems Biology Program, UC San Diego, La Jolla, CA, USA.ORCID 0000-0002-7928-7950
Tianyao XuBioinformatics and Systems Biology Program, UC San Diego, La Jolla, CA, USA.ORCID 0000-0002-2934-7679
Eric M MendenhallMendex Bio, Huntsville, Alabama, USA.ORCID 0000-0002-7395-6295
Hao ChenUniversity of Tennessee Health Science Center, Department of Pharmacology, Addiction Science and Toxicology, Memphis, TN 38103, USA.ORCID 0000-0002-2680-6921
Francesca TeleseDepartment of Psychiatry, UC San Diego, La Jolla, CA, USA.ORCID 0000-0003-3877-0628
Oksana PolesskayaDepartment of Psychiatry, UC San Diego, La Jolla, CA, USA.ORCID 0000-0003-3024-114X
Daniel MunroDepartment of Psychiatry, UC San Diego, La Jolla, CA, USA.ORCID 0000-0002-0724-218X
Abraham A PalmerDepartment of Psychiatry, UC San Diego, La Jolla, CA, USA.ORCID 0000-0003-3634-0747
Alon GorenDepartment of Medicine, UC San Diego, La Jolla, CA, USA.ORCID 0000-0001-5669-9357
Melissa GymrekDepartment of Medicine, UC San Diego, La Jolla, CA, USA.ORCID 0000-0002-6086-3903

Funding

Sequencing CoreP50DA037844 · NIDA · UNIVERSITY OF CHICAGO · PI PALMER, ABRAHAM A · 2014 to 2023
$27.4M
DP30DA060810 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Abraham A Palmer · 2024 to 2026
$5.6M
The role of structural variants and tandem repeats in substance abuse-related behavioral traitsU01DA051234 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GYMREK, MELISSA, PALMER, ABRAHAM A · 2021 to 2025
$3.5M
A framework for interpreting global effects of genetic variants contributing to disease riskR56HG013535 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GOREN, ALON, GYMREK, MELISSA · 2024 to 2024
$757k
NHGRI NIH HHS R56 HG013535NIDA NIH HHS P30 DA060810NIDA NIH HHS P50 DA037844NIDA NIH HHS U01 DA051234
6 · The paper itself

Abstract

While thousands of

Identifiers

PMID42845296
PMCPMC13640548

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.