Evidence map›Paper›PMID 42845286›Full record

ArticlebioRxiv : the preprint server for biology2026

Inhibition of the Lysosomal Amino Acid Sensor SLC38A9 by the Membrane Microprotein SPAR.

Ampon Saeher, Xuelang Mu, Tamir Gonen

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ampon SaeherDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Xuelang MuDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095.
Tamir GonenDepartment of Biological Chemistry, University of California, Los Angeles, Los Angeles, CA 90095.

Funding

TRD4: Design and Engineering of MicroED hardware for nanocrystallization and time resolved studiesP41GM136508 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SPENCE, JOHN CHARLES · 2020 to 2024
$7.6M
MEDIC-MicroED Imaging Center at UCLARM1GM158451 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tamir Gonen, Brent Nannenga · 2025 to 2026
$2.7M
Structural Insights into Leucine Transport for mTORC1 ActivationF32CA278619 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAE HER, AMPON · 2023 to 2025
$226k
NCI NIH HHS F32 CA278619NIGMS NIH HHS P41 GM136508NIGMS NIH HHS RM1 GM158451
6 · The paper itself

Abstract

Long noncoding RNAs encode for microproteins that regulate cellular functions. Small regulatory peptide of amino acid response (SPAR) is a microprotein in the lysosome that responds to amino acid availability of the cell. In this study, we investigated the interactions between SPAR and SLC38A9, a lysosomal amino acid transporter and receptor involved in the mechanistic target of rapamycin 1 (mTORC1) pathway. We found that SPAR binds SLC38A9 and inhibits arginine transport in SLC38A9. Moreover, the downstream recruitment of Rag GTPases is also inhibited when SPAR is present in SLC38A9 liposomes. Docking model shows potential interactions between SPAR and SLC38A9. Together, these findings reveal the mechanism of mTORC1 inhibition through microprotein SPAR and illustrates the power of non long coding RNAs in altering cellular functions.

Identifiers

PMID42845286
PMCPMC13640566

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.