Evidence map›Paper›PMID 42845226›Full record

ArticleAllergy, asthma & immunology research2026

Cadherin-26 Promotes Airway Remodeling via Stabilizing Epithelial Expression of the Epidermal Growth Factor Receptor in Asthma.

Jiali Gao, Gongqi Chen, Chunli Huang, Zhen Wang, Wei Gu, Huiru Jie, Tiantian Xiong, Yuchen Feng, Lingling Yi, Dan Cheng and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jiali GaoDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Gongqi ChenDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0009-4860-1335
Chunli HuangDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0003-0905-7943
Zhen WangDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0002-9151-7958
Wei GuDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Huiru JieDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tiantian XiongDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0009-0007-6954-4857
Yuchen FengDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Lingling YiDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dan ChengDepartment of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China. chengdan729@126.com.ORCID https://orcid.org/0000-0002-5488-1937
Guohua ZhenDepartment of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.ORCID https://orcid.org/0000-0001-5582-7900

Funding

Innovation and Translation Project of Tongji Hospital 2023CXZH006Key Research and Development Program of Hubei Province 2024BCB042National Natural Science Foundation of China 82170036National Natural Science Foundation of China 82570050Noncommunicable Chronic Disease-National Science and Technology Major Project 2024ZD0529900Shandong Provincial Natural Science Foundation for Youths ZR2024QH599
6 · The paper itself

Abstract

purposeActivation of epidermal growth factor receptor (EGFR) signaling in airway epithelial cells leads to epithelial-mesenchymal transformation (EMT) and airway remodeling in asthma. However, the mechanism regulating EGFR expression is not fully understood. We hypothesized that cadherin-26 (CDH26), a highly expressed cadherin in airway epithelium, promotes airway remodeling via regulating EGFR signaling in asthma.

methodsThe expression of CDH26 in airway brush cells of asthmatic patients was examined using quantitative polymerase chain reaction. Airway hyperresponsiveness and remodeling were assessed in the house dust mite (HDM)-sensitized and -challenged

resultsThe expression of CDH26 in airway brush cells was significantly correlated with the thickness of airway basement membrane in asthma patients.

conclusionsCDH26 promoted airway remodeling via stabilizing the epithelial expression of EGFR and sustaining the activation of EGFR signaling in asthma. Thus, CDH26 can be a potential therapeutic target for airway remodeling in asthma.

Indexed as

airway remodelingAsthmacadherinsepidermal growth factor receptorepithelial-mesenchymal transitionknockout micerespiratory mucosasignal transduction

Identifiers

PMID42845226
PMCPMC13655397

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