Evidence map›Paper›PMID 42845214›Full record

ArticleCancer biology & therapy2026

Inhibition of WNT signaling sensitizes CRC cells to anti-tumor effects of retinoids: basis for new drug combinations in oncology.

Victoria O Hunsu, Caroline O B Facey, Lynn M Opdenaker, Bruce M Boman

Abstract read
In one paragraph

Article in Cancer biology & therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Victoria O HunsuCawley Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA.
Caroline O B FaceyCawley Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA.
Lynn M OpdenakerCawley Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA.
Bruce M BomanCawley Center for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE, USA.

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI MELINDA K DUNCAN · 2012 to 2026
$67.2M
NIGMS NIH HHS P20 GM103446
6 · The paper itself

Abstract

Our

Indexed as

Antineoplastic AgentsColorectal NeoplasmsRetinoidsWnt Signaling PathwayAnimalsCell DifferentiationCell Line, TumorCell ProliferationDrug SynergismHumansMiceTretinoinXenograft Model Antitumor AssaysAntineoplastic AgentsRetinoidsTretinoinAPC mutationcolorectal cancerdrug discoveryretinoic acid signalingWNT signaling

Identifiers

PMID42845214
PMCPMC13652067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.