ArticleAnnals of dermatology2026
Clinic-Based Proportion of Psoriatic Arthritis and HLA-B27 Distribution in Korean Psoriasis Patients: A Retrospective Study.
Article in Annals of dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPsoriatic arthritis (PsA) develops in up to one-third of patients with psoriasis over the disease course, and the genetic factors are thought to modulate susceptibility. Although HLA-B27 has long been implicated in PsA, its clinical utility for identifying PsA in East Asian populations remains uncertain.
objectiveWe aimed to estimate the clinic-based prevalence of PsA among Korean psoriatic patients, and to evaluate the diagnostic value of HLA-B27, along with other clinical markers, for PsA.
methodsWe conducted a retrospective, cross-sectional study of 209 patients with psoriasis who presented for their initial dermatology clinic visit at a tertiary referral center.
resultsThe clinic-based prevalence of PsA was 13.9%. HLA-B27 positivity did not show significant difference between patients with PsA and psoriasis not fulfilling Classification Criteria for Psoriatic Arthritis criteria (13.8% vs. 7.8%) and was not associated with PsA or cutaneous disease severity in multivariable analyses. In contrast, nail dystrophy and elevated C-reactive protein (CRP) levels were independently associated with PsA. In this cohort, HLA-B27 demonstrated limited predictive value, whereas nail involvement and elevated CRP levels emerged as more reliable indicators of joint involvement.
conclusionIn this dermatology-based cohort of unselected Korean patients with psoriasis at the initial clinic visit, routine HLA-B27 testing showed limited utility as a screening tool for PsA, whereas nail involvement and elevated CRP levels served as more practical clinical cues for closer joint involvement.
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