Evidence map›Paper›PMID 42844887›Full record

ArticleMicrobiologyOpen2026

Aspergillus niger as a New Endophytic Fungus From Deverra tortuosa: Phytochemical Profile, Molecular Docking, Antimicrobial, Antibiofilm, Antioxidant, and Anticancer Activities.

Samy Selim, Amr H Hashem, Amer Morsy Abdelaziz, Mohamed H Sharaf, Samiah Hamad Al-Mijalli, Mohammed Aladhadh, Emad M Abdallah, Mohammed H Alruhaili, Hattan S Gattan, Alaa A Kashmiry and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Samy SelimDepartment of Clinical Laboratory Sciences, College of Applied Medical Sciences, Jouf University, Sakaka, Saudi Arabia.ORCID https://orcid.org/0000-0003-4025-8586
Amr H HashemBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.ORCID https://orcid.org/0000-0002-0024-3606
Amer Morsy AbdelazizBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.ORCID https://orcid.org/0000-0003-2410-5168
Mohamed H SharafBotany and Microbiology Department, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
Samiah Hamad Al-MijalliDepartment of Biology, College of Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.ORCID https://orcid.org/0000-0003-3160-6008
Mohammed AladhadhDepartment of Food Science and Human Nutrition, College of Agriculture and Food, Qassim University Buraydah, Buraydah, Saudi Arabia.
Emad M AbdallahDepartment of Biology, College of Science, Qassim University, Buraydah, Saudi Arabia.
Mohammed H AlruhailiDepartment of Clinical Microbiology and Immunology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Hattan S GattanSpecial Infectious Agents Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia.
Alaa A KashmiryDepartment of Biological Sciences, College of science, University of Jeddah, Jeddah, Saudi Arabia.
Mohammed AufyDepartment of Pharmaceutical Sciences, Division of Pharmacology and Toxicology, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0002-6693-4530

Funding

Deanship of Scientific Research, Princess Nourah Bint Abdulrahman University PNURSP2026R158
6 · The paper itself

Abstract

Endophytic fungi are recognized as rich sources of bioactive secondary metabolites with promising pharmaceutical applications. In this study, five endophytic fungal isolates were obtained from Deverra tortuosa and evaluated for antimicrobial activity for the first time. Among them, isolate AA1 showed the highest antimicrobial potential and was identified as Aspergillus niger (GenBank accession no. PX273401.1) through morphological and molecular analyses. Phytochemical analysis revealed high levels of flavonoids (496.5 µg/mL), tannins (260.7 µg/mL), phenolics (214.93 µg/mL), and alkaloids (26.45 µg/mL). GC-MS profiling detected several bioactive metabolites, with hexadecenoic acid, docosene, octadecanol, isochiapin B, octadecenoic acid, and octacosanol as major constituents. The fungal extract exhibited potent antibacterial activity against Staphylococcus aureus, Klebsiella pneumoniae, and Bacillus cereus, each with a minimum inhibitory concentration (MIC) of 62.5 µg/mL. It also inhibited biofilm formation by 26.9:55.1% at ½ MIC and demonstrated notable antioxidant activity, with half maximal inhibitory concentration (IC

Indexed as

Anti-Infective AgentsAntineoplastic AgentsAntioxidantsAspergillus nigerBiofilmsEndophytesPhytochemicalsAnimalsAnti-Bacterial AgentsBacillus cereusChlorocebus aethiopsGas Chromatography-Mass SpectrometryHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsMolecular Docking SimulationAnti-Bacterial AgentsAnti-Infective AgentsAntineoplastic AgentsAntioxidantsPhytochemicalsantibiofilmantimicrobialantioxidantAspergillusbioactive compoundsDeverra tortuosaendophytes

Identifiers

PMID42844887
PMCPMC13646716

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.