ArticleNeurogastroenterology and motility2026
Biomechanical Assessment During High-Resolution Impedance Manometry Enhances Characterization of Inconclusive Esophagogastric Junction Outflow Obstruction.
Article in Neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEsophagogastric junction outflow obstruction (EGJOO) identified on high-resolution manometry (HRM) remains a clinically heterogeneous and inconclusive finding. Additional complementary testing with functional lumen imaging probe (FLIP) or timed barium esophagram (TBE) is recommended to confirm clinically relevant obstruction. We aimed to assess the association of novel Four-Dimensional (4D) HRM metrics against FLIP and TBE outcomes among symptomatic patients with inconclusive EGJOO on HRM.
methodsAdult patients with inconclusive HRM-EGJOO who completed corresponding FLIP and TBE studies were identified for inclusion in a cross-sectional, retrospective study. Primary 4D HRM metrics of EGJ opening, EGJ distensibility index (4D EGJ-DI), and 4D maximum EGJ diameter were analyzed relative to reference outcomes defined by FLIP and esophagram.
resultsAmong 123 patients (mean age 59 years; 60% female), 4D EGJ-DI and 4D maximum EGJ diameter differed significantly across FLIP and TBE outcome categories (all p < 0.01). Lower 4D EGJ-DI and lower 4D maximum EGJ diameter were associated with reduced EGJ opening on FLIP and abnormal retention on esophagram. There were 0 patients with normal EGJ opening on FLIP that had 4D maximum EGJ diameter < 8.0 mm and 0 patients with reduced EGJ opening on FLIP that had a 4D EGJ-DI > 2.2 mm
conclusionsBy integrating biomechanical assessment of EGJ opening with conventional pressure metrics, 4D HRM provides complementary physiologic information for evaluating esophageal motor function. This additional information may improve characterization of patients with inconclusive EGJOO.
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