Evidence map›Paper›PMID 42844645›Full record

ArticleJournal of extracellular vesicles2026

C1qc Mediates Blood-Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia-Derived Migrasomes.

Mengyuan Li, Zhihua Li, Dengpan Song, Fang Wang, Mengzhao Feng, Chi-Tai Yeh, Tingting Zhai, Menghan Deng, Yanyan Sun, Junyang Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Mengyuan Li *Department of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0003-1789-5261
Zhihua Li *Department of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Dengpan SongDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0001-5240-7601
Fang WangDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0002-1474-2297
Mengzhao FengDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0002-0933-1899
Chi-Tai YehDepartment of Medical Research & Education, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.ORCID https://orcid.org/0000-0001-5189-9755
Tingting ZhaiDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Menghan DengDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Yanyan SunDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Junyang WangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Xuemei ChenDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Yating WangSchool of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Qiong YangThe First Clinical Medical School, Department of Geriatrics, Hubei University of Chinese Medicine, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei, China.ORCID https://orcid.org/0009-0008-6471-7410
Moxin WuDepartment of Medical Laboratory, Jiujiang Clinical Precision Medicine Research Center, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China.ORCID https://orcid.org/0000-0001-5823-3657
Xiaoping YinDepartment of Neurology, Jiujiang Clinical Precision Medicine Research Center, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China.
Junmin WangDepartment of Human Anatomy, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.
Jian WangAging Decoding and Regeneration Institute, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0003-2291-640X
Fuyou GuoDepartment of Neurosurgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.ORCID https://orcid.org/0000-0002-6347-7653

Funding

Key Project of International Science and Technology Cooperation, Science and Technology Department of Henan Province 241111520600Leading Project of Henan Province Young Medical Research LJRC2023010National Natural Science Foundation of China 32471043
6 · The paper itself

Abstract

Extracellular vesicles (EVs) are essential for intercellular communication and significantly influence neuroimmune responses after intracerebral haemorrhage (ICH). This study elucidates the immune mechanisms underlying secondary brain injury following ICH by identifying microglia-derived migrasomes. By integrating immune cell clustering analysis from single-cell RNA sequencing (scRNA-seq) with Mendelian randomization, we identified five key genes associated with ICH. Further experiments revealed that C1qc accumulates around hematomas, worsening blood‒brain barrier (BBB) disruption through migrasome-mediated pathways. Our results showed that microglial migrasomes transport C1qc to induce pyroptosis in vascular endothelial cells, thereby compromising BBB integrity. Genetic ablation of C1qc substantially attenuated this BBB damaging effect, C1qc-deficient migrasomes exhibited protective properties. Our findings, for the first time, reveal the mechanistic role of C1qc and migrasomes in ICH pathogenesis and establish microglia-derived migrasomes as promising therapeutic targets, providing novel avenues to improve neurologic outcomes after ICH.

Indexed as

Blood-Brain BarrierCerebral HemorrhageComplement C1qMicrogliaAnimalsDisease Models, AnimalEndothelial CellsMaleMiceMice, Inbred C57BLComplement C1qblood‒brain barrierC1qcintracerebral haemorrhagemicrogliamigrasomes

Identifiers

PMID42844645
PMCPMC13645951

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.