Bos indicus cattle resistant to digital dermatitis exhibit a balanced proinflammatory cytokine response upon exposure to Treponema phagedenis in contrast to Bos taurus cattle.

Thomas Démoulins, Thatcha Yimthin, Laura Tassera, Isabelle Brodard, Lukas Eggerschwiler, Andrew Hemphill, Joerg Jores, Peter Kuhnert

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Article in Veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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5 · Who and what money

Authors and funding

8 authors.

Thomas DémoulinsInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland. thomas.demoulins@unibe.ch.ORCID https://orcid.org/0000-0003-0654-5813

Thatcha Yimthin *Institute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.ORCID http://orcid.org/0009-0004-4489-172X

Laura Tassera *Institute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.

Isabelle BrodardInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.ORCID http://orcid.org/0000-0003-2942-1792

Lukas EggerschwilerResearch Contracts Animals Group, Agroscope, 1725, Posieux, Switzerland.ORCID http://orcid.org/0000-0001-8509-9625

Andrew HemphillInstitute of Parasitology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.ORCID http://orcid.org/0000-0002-0622-2128

Joerg JoresInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland.ORCID http://orcid.org/0000-0003-3790-5746

Peter KuhnertInstitute of Veterinary Bacteriology, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern, 3012, Bern, Switzerland. peter.kuhnert@unibe.ch.ORCID http://orcid.org/0000-0002-1575-5225

Funding

European Union's Horizon 2020 research and innovation programme 101000365

6 · The paper itself

Abstract

Bovine digital dermatitis (BDD) is a globally distributed infectious hoof disease that negatively impacts the wellbeing and productivity of the affected animal. Treponema species and in particular Treponema phagedenis are the microbes strongly associated with the disease. Recently, it has been reported that Bos indicus cattle are more resistant to BDD and to the colonization by Treponema phagedenis in contrast to many Bos taurus breeds. This study investigated whether Bos indicus mount a different immune response to Treponema phagedenis compared with Bos taurus cattle, to better understand the different disease outcome in the two subspecies. Therefore, we exposed freshly isolated primary bovine blood cells to Treponema phagedenis and dissected subsequent bovine immune responses. The comparison between the two subspecies revealed significant different immune responses to Treponema phagedenis. We observed a stronger Th1/proinflammatory cytokine induction in Bos taurus animals mainly driven by CD4

Indexed as

Cattle DiseasesCytokinesDigital DermatitisTreponemaTreponemal InfectionsAnimalsCattleSpecies SpecificityCytokinesBos indicusBos taurusbovine digital dermatitisDichelobacter nodosusmatrix metalloproteinaseproinflammatory immune responseTreponema phagedenis

Identifiers

PMID42844642

DOI10.1186/s13567-026-01848-1

PMCPMC13644106

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.