Evidence map›Paper›PMID 42844615›Full record

ReviewJournal of biomedical science2026

Primary cilium as a sensory organelle and metabolic hub in health and diseases.

Huan-Tzu Hou, Yu-Ying Chao, Jie-Ning Li, I-Chen Peng, Tzu-Chien Lin, Wen-Tai Chiu, Chia-Yih Wang, Shaw-Jenq Tsai

Abstract readReview
In one paragraph

Review in Journal of biomedical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Huan-Tzu Hou *Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Yu-Ying Chao *Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Jie-Ning LiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
I-Chen PengDepartment of Life Sciences, National Cheng Kung University, Tainan City, 701, Taiwan.
Tzu-Chien LinInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Wen-Tai ChiuInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan.
Chia-Yih WangInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan. b89609046@gmail.com.
Shaw-Jenq TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, 70101, Taiwan. seantsai@ccu.edu.tw.

Funding

National Science and Technology Council NSTC-112-2320-B-006-019-MY3National Science and Technology Council NSTC-114-2320-B-006-019-MY3National Science and Technology Council NSTC-114-2811-B-006-052
6 · The paper itself

Abstract

Primary cilia are microtubule-based organelles protruding from the cell surface, which are conventionally understood as passive cellular antennae that detect extracellular stimuli. However, emerging evidence redefines these microtubule-based organelles as dynamic, bidirectional hubs that integrate environmental sensing with cellular metabolic adaptation. By selectively compartmentalizing receptors, ion channels, transporters, and signaling components, they function as specialized signal-processing compartments that receive, integrate, amplify, and relay information to coordinate cellular metabolism, adaptation, and cell-fate determination. Cilia-dependent signaling pathways regulate glucose and lipid metabolism, Ca

Indexed as

CiliaSignal TransductionAnimalsHumansCiliopathiesGlucose and lipid metabolismHuman diseaseMechanotransductionMetabolic signalingMitochondrial homeostasisNutrient sensingPrimary cilia

Identifiers

PMID42844615
PMCPMC13644013

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.