Evidence map›Paper›PMID 42844530›Full record

ArticleAnnals of surgical oncology2026

Prophylactic Pyloric Dilatation and its Impact on Early Delayed Gastric Conduit Emptying and Pneumonia Post-esophagectomy: A Multi-centre Cohort Study.

Jonathan Sivakumar, Shaun Chew, Amass Zheng, Cuong P Duong, John Spillane, Ahmad Aly, Shichao Chen, Ian Hughes, David S Liu

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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Jonathan SivakumarDivision of Cancer Surgery, Melbourne, VIC, Australia. sivakumar.jonathan@gmail.com.ORCID http://orcid.org/0000-0003-1756-5780
Shaun ChewDivision of Cancer Surgery, Melbourne, VIC, Australia.
Amass ZhengUpper Gastrointestinal Surgery Unit, Austin Health, Melbourne, VIC, Australia.
Cuong P DuongDivision of Cancer Surgery, Melbourne, VIC, Australia.
John SpillaneDivision of Cancer Surgery, Melbourne, VIC, Australia.
Ahmad AlyDepartment of Surgery, The University of Melbourne, Melbourne, VIC, Australia.
Shichao ChenOffice for Research Governance and Development, Gold Coast University Hospital, Gold Coast, QLD, Australia.
Ian HughesOffice for Research Governance and Development, Gold Coast University Hospital, Gold Coast, QLD, Australia.
David S LiuDivision of Cancer Surgery, Melbourne, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEarly delayed gastric conduit emptying (DGCE) and pneumonia are among the most common complications following oesophagectomy. These issues can be challenging to address during minimally invasive surgery with pyloroplasty or pyloromyotomy. This study evaluated the impact of prophylactic endoscopic pyloric balloon dilatation (PBD) on early postoperative outcomes.

methodsConsecutive patients undergoing oesophagectomy with gastric conduit reconstruction for cancer at two Australian tertiary centres (2017-2025) were retrospectively analysed. From 2023, intraoperative endoscopic-assisted PBD using a 20 mm balloon inflated for two minutes across the pylorus was adopted as standard practice. Primary endpoints were early DGCE and hospital-acquired pneumonia (HAP) within 30 days; secondary endpoints included nasogastric tube (NGT) output and duration, and hospital length-of-stay. Associations were examined using multivariable logistic regression and inverse-probability-weighted regression adjustment (IPWRA).

resultsOf 187 patients, 40 (21.4%) received PBD. Compared with controls, PBD was associated with reduced DGCE (15% vs. 40.1%; odds ratio [OR] 0.26, 95% confidence interval [CI] 0.11-0.65) and HAP (20% vs. 40.8%; OR 0.36, 95% CI 0.17-0.80). Pyloric balloon dilatation independently predicted lower DGCE (OR 0.33, 95% CI 0.12-0.91) and HAP (OR 0.18, 95% CI 0.05-0.67), with absolute risk reductions of 27.4% and 30.8% respectively on IPWRA analysis. Pyloric balloon dilatation was also associated with lower postoperative NGT outputs, earlier NGT removal (median 6 [interquartile range (IQR) 4-11] vs. 4 [IQR 3-7] days; p = 0.032), and shorter hospital length of stay (median 13 [IQR 9-22] vs. 9 [IQR 8-16] days; p = 0.007).

conclusionsProphylactic PBD was associated with lower early DGCE and pneumonia. This enabled earlier nasogastric tube removal and shorter hospital stay, supporting its integration into contemporary practice.

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