Evidence map›Paper›PMID 42844526›Full record

ArticleAnnals of surgical oncology2026

Outcomes of Elderly Patients with Colorectal Liver Metastases Treated with Liver-Directed Therapies.

Nafeesah Fatimah, Morgan F Pettigrew, Victoria F Peters, Christine F Johansen, Matthew R Porembka, Alex C Kim, John C Mansour, Adam C Yopp, Sam C Wang

Abstract read
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Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Nafeesah FatimahDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Morgan F PettigrewDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Victoria F PetersDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Christine F JohansenDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Matthew R PorembkaDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Alex C KimDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
John C MansourDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Adam C YoppDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Sam C WangDivision of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. Sam.Wang@UTSouthwestern.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver-directed therapy (LDT) is an essential component of multimodal management of colorectal liver metastases (CRLM), yet older adults are less likely to receive liver-directed or curative-intent treatment. We evaluated presentation, treatment patterns, and outcomes among elderly patients with CRLM.

methodsWe retrospectively reviewed patients with CRLM treated at the University of Texas Southwestern Medical Center and Parkland Memorial Hospital from 2016 to 2023. Liver-directed therapy was defined as liver resection, hepatic artery infusion pump therapy, ablation, liver-directed radiation including external beam radiation and stereotactic body radiation, transarterial chemoembolization, and/or Y-90 radioembolization. The primary outcome was overall survival (OS); the secondary outcome was receipt of LDT. Cox proportional hazards regression identified factors associated with OS among patients aged ≥70 years.

resultsAmong 852 patients, 710 were aged <70 years and 142 were aged ≥70 years. Liver metastasis number, bilobar involvement, CEA level, and extrahepatic disease were similar between age groups. Older adults were less likely to receive LDT than younger patients (20% vs. 40%, p < 0.001). Among patients who underwent hepatic resection, perioperative outcomes were similar by age. Among older adults, LDT was associated with longer median OS than no LDT (44 vs. 9 months, p < 0.001). Among patients receiving LDT, median OS was comparable between age groups (44 vs. 52 months, p = 0.19). Performance status, CEA ≥200 ng/mL, chemotherapy, and LDT were independently associated with OS.

conclusionsOlder adults with CRLM were less likely to receive LDT. Among selected older adults, receipt of LDT was associated with longer OS than no LDT. Chronological age alone should not preclude consideration of LDT.

Identifiers

PMID42844526

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