Evidence map›Paper›PMID 42844479›Full record

ArticleNature2026

Mechanism of spliceosome termination.

Vytaute Boreikaite, Rupert Faraway, Matthias K Vorländer, Alexander W Phillips, Leonie Opitz, Moritz Wanke, George Yakoub, Gerald Raffl, Laura Fin, Román González-Prieto and 3 more

Abstract read
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In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Vytaute BoreikaiteResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
Rupert FarawayResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
Matthias K VorländerResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
Alexander W PhillipsResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0002-6689-9632
Leonie OpitzResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0009-0001-9351-8620
Moritz WankeMax Perutz Labs, Vienna BioCenter (VBC), Vienna, Austria.
George YakoubDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0003-2727-7651
Gerald RafflMax Perutz Labs, Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0003-0210-0286
Laura FinResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria.
Román González-PrietoAndalusian Centre for Regenerative Medicine and Molecular Biology (CABIMER), Universidad de Sevilla-CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Sevilla, Spain.ORCID http://orcid.org/0000-0001-8997-2321
Martijn S LuijsterburgDepartment of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Stefan L AmeresMax Perutz Labs, Vienna BioCenter (VBC), Vienna, Austria.ORCID http://orcid.org/0000-0002-8248-3098
Clemens PlaschkaResearch Institute of Molecular Pathology (IMP), Vienna BioCenter (VBC), Vienna, Austria. clemens.plaschka@imp.ac.at.ORCID http://orcid.org/0000-0002-6020-9514

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

After excising an intron from pre-mRNA, the spliceosome remains trapped in a non-productive complex bound to the intron

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.