Evidence map›Paper›PMID 42844465›Full record

ArticleNature2026

tRNA dosage regulates lineage dependency and resistance in prostate cancer.

Yeon Soo Kim, Sonali Arora, Dave Young, Ava Tsou, Amy Shiuan, Cynthia L Wladyka, Dmytro Rudoy, Jin Yeong Kim, Jennifer A Waters, Samantha L Schuster and 17 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Yeon Soo KimHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Sonali AroraHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6661-3024
Dave YoungHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Ava TsouHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Amy ShiuanHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Cynthia L WladykaHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Dmytro RudoyHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jin Yeong KimHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Jennifer A WatersHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Samantha L SchusterHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Ilsa M ColemanHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Mridu KapurDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Marek SobczykDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0009-0004-5698-5627
Christopher D KatanskiDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Amin M Bayat TorkDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-2944-046X
Wen ZhangDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8577-2613
Peter S NelsonHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-5451-5726
Gavin HaHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7578-7272
Michael C HaffnerHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.
Eva CoreyDepartment of Urology, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9244-3807
Colm MorrisseyDepartment of Urology, University of Washington, Seattle, WA, USA.
Yuzhuo WangProstate Centre at Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0002-9749-8591
Arvind R SubramaniamComputational Biology Section of the Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6145-4303
John K LeeDivision of Hematology/Oncology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-6570-2180
Susan L AckermanDepartment of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Tao PanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA. taopan@uchicago.edu.ORCID http://orcid.org/0000-0003-1096-8405
Andrew C HsiehHuman Biology Division, Fred Hutchinson Cancer Center, Seattle, WA, USA. ahsieh@fredhutch.org.ORCID http://orcid.org/0000-0002-0897-1050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lineage plasticity underlies therapeutic resistance in cancer

Identifiers

PMID42844465

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.