ArticleArchives of virology2026
Biphasic phenotypic adaptation of sheeppox virus consequent to serial passaging in heterologous host cell type.
Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sheeppox virus (SPPV) is a highly host-restricted capripoxvirus, and its biological behavior in heterologous cells remains poorly defined. Although heterologous cell lines such as Vero cells are widely used for SPPV propagation and vaccine production, the effects of prolonged adaptation to these systems on viral replication and release dynamics have not been systematically examined. In this study, the SP3-Nur strain of SPPV (PV167793.1) was serially passaged 45 times in Vero cells. The parent virus (P0) was assessed in lamb testicular (LT) cells, while Vero-adapted passage levels (P15, P30, and P45) were evaluated in both Vero and LT cells to examine how passage levels affect viral replication and extracellular virus release. Replication kinetics were quantified at 0, 2, 4, and 6 days post-infection (DPI) using plaque-forming unit (PFU) assays and quantitative PCR (qPCR). In Vero cells, while virus production was increased from 2.54 log
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