ArticleAnalytical and bioanalytical chemistry2026
Soluble polymeric system reducing non-specific interactions in plasmonic biosensor-based detection of carcinoembryonic antigen.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-specific interactions in detection systems are among the main factors limiting the performance of surface-sensitive biosensor technologies. Here, we report on a new macromolecular blocker based on low-fouling poly[N-2-(hydroxypropyl)methacrylamide] (HPMA) copolymer containing hydrophobic comonomer units, which can reduce non-specific interactions improving the limit of detection when used in conjunction with a sandwich assay employing functional gold nanoparticles (AuNPs). The poly(HPMA) blocker adopts a relatively compact or collapsed conformation in PBS buffer, potentially indicating significant intramolecular interactions in an extended random coil. In a model experiment, we use this approach with a surface plasmon resonance biosensor for the detection of carcinoembryonic antigen, a biomarker of colorectal cancer. We demonstrate that the poly(HPMA) blocker reduced the AuNP non-specific binding and provided a high reduction of the non-specific binding when compared to conventional additives such as bovine serum albumin (BSA) and Tween. A combination of poly(HPMA) blocker and BSA was found to be the most effective additive, providing a 2.9-fold decrease of AuNP non-specific sensor response and a 2.8-fold improvement of the limit of detection compared to BSA alone.
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