ArticleNature neuroscience2026
Astrocytes regulate axonal mitochondrial transport deficits in C9ORF72 amyotrophic lateral sclerosis motor neurons.
Maria Stavrou, Áine Bríd Heffernan, Roderick N Carter, Owen Dando, Zoeb Jiwaji, Karen Burr, Jyoti Nanda, David Villarroel-Campos, Alya Masoud Abdelhafid, Justyna Cholewa-Waclaw and 6 more
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In one paragraphArticle in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
16 authors.
Áine Bríd HeffernanUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK.
Roderick N CarterUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK.
Karen BurrUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK.
Jyoti NandaUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK.
David Villarroel-CamposDepartment of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0003-4250-7216 Alya Masoud AbdelhafidDepartment of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.
Justyna Cholewa-WaclawInstitute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.
David StoryUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK.
Giampietro SchiavoDepartment of Neuromuscular Diseases and UCL Queen Square Motor Neuron Disease Centre, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID http://orcid.org/0000-0002-4319-8745 Siddharthan ChandranUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK. siddharthan.chandran@ed.ac.uk.ORCID http://orcid.org/0000-0001-6827-1593 Bhuvaneish T SelvarajUK Dementia Research Institute at University of Edinburgh, University of Edinburgh, Edinburgh BioQuarter, Chancellor's Building, Edinburgh, UK. bthangar@ed.ac.uk.ORCID http://orcid.org/0000-0001-7299-0910 Funding
RCUK | Medical Research Council (MRC) (MR/T000708/1)Wellcome Trust (Wellcome) (223022/Z/21/Z)
6 · The paper itselfAbstract
Disrupted axonal transport and astrocyte dysfunction are implicated in amyotrophic lateral sclerosis (ALS). Here we show these processes are linked-human-induced pluripotent stem-cell-derived astrocytes carrying the C9ORF72 mutation disrupt mitochondrial axonal transport and mitochondrial function in cocultured motor neurons (MNs). Conversely, isogenic gene-corrected astrocytes or boosting astrocytic mitochondrial bioenergetics rescue axonal mitochondrial transport deficits in C9ORF72 MNs. Our results delineate a non-cell-autonomous role for astrocytes in regulating mitochondrial transport along axons in ALS models.
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