Evidence map›Paper›PMID 42844360›Full record

ArticleSkeletal radiology2026

Atypical spindle cell/pleomorphic lipomatous tumor with sarcomatous transformation during recurrence.

Jens De Temmerman, Thomas Van Den Berghe, Fleur Cordier, Desirée Dorleijn, Kiara Peirens, Maryse Lejoly, Ruben Rimbaut, Gwen Sys, David Creytens, Koenraad L Verstraete

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Article in Skeletal radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jens De TemmermanDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium. jens.detemmerman@ugent.be.ORCID http://orcid.org/0009-0005-6981-3231
Thomas Van Den BergheCRIG, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
Fleur CordierDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Desirée DorleijnCRIG, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
Kiara PeirensCRIG, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
Maryse LejolyCRIG, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
Ruben RimbautFaculty of Engineering and Architecture, Ghent University, Ghent, Belgium.
Gwen SysCRIG, Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.
David CreytensDepartment of Diagnostic Sciences, Ghent University, Ghent, Belgium.
Koenraad L VerstraeteDepartment of Radiology and Medical Imaging, Ghent University Hospital, Ghent, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently defined adipocytic neoplasm with broad morphological variability. While generally benign, a small subset of ASPLT can demonstrate locally aggressive behavior with recurrences after incomplete resection. There is only limited description of the radiologic features of ASPLT in the literature. This case report presents a unique longitudinal case of a 75-year-old woman with an ASPLT in the subcutaneous tissue of the left lower leg. Following two incomplete resections, the tumor recurred twice over 38 months, each time with increasing volume and growth rate. The second recurrence demonstrated abrupt histological transition from low-grade ASPLT to high-grade undifferentiated sarcoma, with underlying RB1 deletion, an additional NF1 gene mutation, and a complex genomic profile. The tumors demonstrated low to intermediate signal intensity on T1-weighted imaging and heterogeneous enhancement on T1-weighted fat-saturated images after contrast agent injection. Dynamic contrast-enhanced (DCE)-MRI revealed heterogeneous perfusion patterns correlating to sarcomatous regions. Elevated (semi-)quantitative DCE-MRI parameters, reflecting increased vascularization, perfusion, and high capillary permeability, were observed in histologically high-grade areas compared with low-grade regions. To the best of our knowledge, this is the first in-depth clinicoradiological study documenting transformation of an ASPLT into a high-grade undifferentiated sarcoma following incomplete surgery. This case also emphasizes the diagnostic value of DCE-MRI in identifying biologically aggressive (high-grade) regions within ASPLTs undergoing sarcomatous transformation.

Indexed as

Atypical spindle cell/pleomorphic lipomatous tumor(DCE-)MRIDedifferentiated liposarcomaHigh-grade undifferentiated sarcomaLiposarcomaSarcomatous transformationTumor recurrence

Identifiers

PMID42844360

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.