ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Comparison of prenatal self-report of tobacco use to direct measurement of umbilical cord cotinine.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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Authors and funding
17 authors.
Funding
Abstract
objectiveThis study compared maternal self-reports of prenatal tobacco product use with biochemically confirmed cotinine in umbilical cord tissue in newborns exposed to opioids in utero and unexposed controls. STUDY
designSecondary data analysis on 179 pregnant women and newborns. Chi-square and t-tests were used to compare sociodemographic factors of those who did and did not self-report tobacco use.
resultsMean (SD) maternal age was 29.5 years (5.0); 85.2% had public insurance, and 92 (51.4%) took opioids prenatally. Ninety-five (53.1%) mothers self-reported prenatal tobacco product and/or e-cigarette use, with cord cotinine detected in 98.9%. Of the 84 reporting no use, cotinine detection was 34.5%, resulting in moderate agreement (Gwet's AC1 = 0.68 (0.571, 0.788), p < 0.001). Of those reporting no use, 27 (32.9%) had cotinine detected (p = 0.038).
conclusionsBiochemically verified cotinine detection was much higher than maternal self-reports of prenatal tobacco use. Inquiring about household and community smoke exposure may help inform optimal care.
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Registered trials
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