Evidence map›Paper›PMID 42844326›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

The role of prophylactic arginine supplementation for prevention of bronchopulmonary dysplasia in extremely preterm infants.

Stefani M Doucette, Sunil Kumar Jain, Harish Amin, Amina Benlamri, Muhammad Hussain, Selphee Tang, Vineet Bhandari, Abhay Lodha

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stefani M DoucetteDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. smdoucet@ucalgary.ca.ORCID http://orcid.org/0000-0002-3999-6760
Sunil Kumar JainUniversity of Texas Medical Branch, Division of Neonatology, Galveston, TX, USA.ORCID http://orcid.org/0000-0002-0592-6705
Harish AminDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Amina BenlamriDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Muhammad HussainUniversity of Texas Medical Branch, Division of Neonatology, Galveston, TX, USA.
Selphee TangAlberta Health Services, Calgary, AB, Canada.
Vineet BhandariDivision of Neonatology, The Children's Regional Hospital at Cooper / Cooper Medical School of Rowan University, Camden, NJ, USA.ORCID http://orcid.org/0000-0002-4900-6636
Abhay LodhaDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID http://orcid.org/0000-0001-7309-9011

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveEvaluate association between routine arginine supplementation for the first 28 days of life and incidence of bronchopulmonary dysplasia (BPD) and mortality for preterm infants <29 weeks gestational age (GA). STUDY

designThis retrospective cohort study assessed preterm infants <29 weeks' GA before and after introduction of routine prophylactic arginine supplementation for the first 28 days of life. The primary outcome was bronchopulmonary dysplasia (BPD), defined as oxygen dependency at 36 weeks' postmenstrual age (PMA) and classified by severity using Jensen's criteria. Univariate and multivariable regression analyses were performed.

resultsOverall, 676 preterm infants <29 weeks GA were included. The incidence of any BPD decreased from 85% to 73% following introduction of routine arginine supplementation. The adjusted odds ratios (aORs) for any BPD and severe BPD (Grade 2 and 3) were 0.50 (95% CI 0.27-0.90) and 0.94 (95% CI 0.41-2.14), respectively. The composite outcome of BPD or mortality was also reduced (aOR 0.51; 95% CI 0.28-0.91).

conclusionIn preterm infants born at <29 weeks' GA, prophylactic arginine supplementation during the first 28 days of life was associated with reduced odds of BPD and the composite outcome of BPD or death before 36 weeks' PMA, but not with severe BPD.

Identifiers

PMID42844326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.