ArticleInternational journal of obesity (2005)2026
Bariatric surgery and risk of dementia and Parkinson's disease in patients with obesity.
Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
8 authors.
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Abstract
objectiveWe aimed to evaluate the association between bariatric surgery (BS) and the incidence of dementia and Parkinson's disease. To assess consistency with established benefits of BS, we examined its association with cardiovascular disease, obesity-associated cancers, and all-cause mortality.
methodsWe conducted a longitudinal cohort study using electronic health records from TriNetX network. Patients aged ≥16 years with at least one BMI record of ≥35 kg/m
resultsAfter matching, there were 32,552 individuals each in the BS and non-BS group. The median follow-up was 4.7 years in individuals with BS and 5.9 years in those without. Compared to the non-BS group, individuals who underwent BS had significantly reduced incidence rates of dementia (hazard ratio 0.48, 95% CI: 0.39-0.58) and Parkinson's disease (0.70; 0.51-0.96). Similar associations were observed for CVD (0.53; 0.51-0.56); obesity-associated cancers (0.66; 0.60-0.72) and all-cause death (0.46; 0.41-0.51). Survival probability at 20-years was 84.7% (95% CI: 71.1-92.3%) in the BS group vs 81.8% (77.5-85.4%) in those without.
conclusionBS was associated with a lower incidence of dementia and Parkinson's disease in individuals with BMI ≥ 35 kg/m
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