Evidence map›Paper›PMID 42843928›Full record

Trial reportBMJ mental health2026

Early interventions for primary care patients with stress-related mental ill health: a randomised controlled non-inferiority trial of a nurse-led collaborative care intervention versus cognitive behavioural therapy.

Evelina Kontio, Victoria Sennerstam, Frank Svärdman, Conrad Samuelsson, Janina Hettman, Nathalie Broman, Ludwig Franke Föyen, Kersti Ejeby, Elin Lindsäter, Erik Hedman-Lagerlöf

Abstract readRandomized Controlled TrialEquivalence Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Evelina KontioDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden evelina.kontio@ki.se.ORCID http://orcid.org/0009-0000-0759-7258
Victoria SennerstamDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Frank SvärdmanDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Conrad SamuelssonDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Janina HettmanAcademic Primary Care Center, Gustavsberg University Primary Care Center, Stockholm, Sweden.
Nathalie BromanAcademic Primary Care Center, Gustavsberg University Primary Care Center, Stockholm, Sweden.
Ludwig Franke FöyenDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Kersti EjebyAcademic Primary Care Center, Gustavsberg University Primary Care Center, Stockholm, Sweden.
Elin LindsäterDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.
Erik Hedman-LagerlöfDepartment of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStress-related mental ill health is highly prevalent, and most individuals first seek help in primary care where access to psychological support is often limited.

objectiveTo test whether nurse-led collaborative care (CC) is non-inferior to cognitive behavioural therapy delivered as psychologist-guided self-help (GSH-CBT) in reducing stress for adult primary care patients with stress-related mental ill health.

methodsA randomised controlled non-inferiority trial where 172 adult primary care patients with mild to moderate stress-related mental ill health were allocated to nurse-led CC or GSH-CBT (1:1). The primary outcome was the Perceived Stress Scale-10 administered every 3 weeks during the 12-week treatment phase. The a priori non-inferiority margin was 0.3

findingsIn both conditions, participants showed large, significant within-group improvements on the primary outcome and all secondary outcomes. The primary outcome showed a small between-group difference (

conclusionsNurse-led CC was not non-inferior to GSH-CBT. Effect differences were small, but improvements were slightly larger in GSH-CBT. CLINICAL IMPLICATIONS: Given that nurse-led CC is safe, easy to administer, and that significant within-group improvements were observed across all measures, this intervention could be a viable option in primary care settings where psychologist-delivered treatment is limited.

Indexed as

Cognitive Behavioral TherapyStress, PsychologicalAdultDepressionFemaleHumansMaleMiddle AgedPrimary Health CareQuality of LifeTreatment Outcome

Identifiers

PMID42843928
PMCPMC13646939

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.