Evidence map›Paper›PMID 42843119›Full record

ArticleThe journal of nutrition, health & aging2026

Criterion validity of brief, comprehensive, and latent measures of intrinsic capacity against frailty, disability, and mortality in older adults.

Sunyoung Kim, Lan Luo, Sandra M Shi, Chan Mi Park, Kevin T Pritchard, Miji Kim, Chang Won Won, Dae Hyun Kim

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Article in The journal of nutrition, health & aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Sunyoung KimDepartment of Family Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School Affiliate, Boston, MA, USA.
Lan LuoHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School Affiliate, Boston, MA, USA.
Sandra M ShiHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School Affiliate, Boston, MA, USA; Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Chan Mi ParkHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School Affiliate, Boston, MA, USA; Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Kevin T PritchardHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School Affiliate, Boston, MA, USA.
Miji KimDepartment of Health Sciences and Technology, College of Medicine, Kyung Hee University, Seoul, South Korea. Electronic address: mijiak@khu.ac.kr.
Chang Won WonDepartment of Family Medicine, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. Electronic address: chunwon@khu.ac.kr.
Dae Hyun KimHinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Harvard Medical School Affiliate, Boston, MA, USA; Division of Gerontology, Beth Israel Deaconess Medical Center, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntrinsic capacity (IC), the composite of physical and mental capacities, underpins the WHO Integrated Care for Older People (ICOPE) program. IC may be measured as a brief screen, a comprehensive assessment, or a latent factor score; whether the simpler measures retain the prognostic information of the complex ones remains untested within a single population.

methodsIn the nationwide Korean Frailty and Aging Cohort Study, 3011 community-dwelling adults aged 70-84 years (mean age, 76.0 [SD, 3.9] years; 52.5% women) were assessed for frailty and for activities of daily living (ADL) and instrumental ADL (IADL) disability and followed for mortality (median, 8.0 years). IC was measured by a Korean ICOPE screening score (K-ICOPE), a comprehensive clinical score (CIC), and a bifactor latent score (LIC); differences in discrimination were tested formally.

resultsDiscrimination for frailty rose with measurement intensity (area under the curve, 0.82, 0.86, 0.90; all pairwise P < .001) but not for ADL or IADL disability (all P ≥ .25). There were 500 deaths. Adjusted for sociodemographics and multimorbidity, each 1-SD higher IC was associated with lower mortality (hazard ratio 0.83 [95% CI, 0.75-0.91], 0.71 [0.64-0.78], 0.65 [0.58-0.73]), with closely similar discrimination (C statistic, 0.723, 0.731, 0.736; largest difference, 0.013 [0.005-0.021]). Discrimination from IC alone was lower and similar across measures (0.583, 0.604, 0.585).

conclusionsMeasurement intensity improved the characterization of frailty but added little to the ranking of long-term mortality risk. Because K-ICOPE was aligned by construction to the latent structure, these findings support the potential feasibility of brief ICOPE-style screening rather than validating the WHO instrument.

Indexed as

AgingCohort studiesFunctional declineGeriatric assessmentICOPE

Identifiers

PMID42843119
PMCPMC13676973

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