Evidence map›Paper›PMID 42842841›Full record

ArticleJCO precision oncology2026

Determining the Causal Effect of Neurotrophic Tropomyosin Receptor Kinase Gene Fusions on Survival Prognosis for Adult Patients With Advanced Cancers.

Emanuel Krebs, Nirupama Tamvada, Deirdre Weymann, Howard J Lim, Stephen Chia, Cheryl Ho, Dean A Regier

Abstract read
In one paragraph

Article in JCO precision oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emanuel KrebsRegulatory Science Lab, BC Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-6590-8728
Nirupama TamvadaRegulatory Science Lab, BC Cancer Research Institute, Vancouver, BC, Canada.ORCID 0009-0003-3285-4115
Deirdre WeymannRegulatory Science Lab, BC Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0002-3072-5657
Howard J LimDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0002-5814-714X
Stephen ChiaDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0001-7070-4386
Cheryl HoDivision of Medical Oncology, BC Cancer, Vancouver, BC, Canada.ORCID 0000-0002-5922-3984
Dean A RegierRegulatory Science Lab, BC Cancer Research Institute, Vancouver, BC, Canada.ORCID 0000-0001-8876-0511

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUncertainty about the prognostic significance of neurotrophic tropomyosin receptor kinase (

methodsWe used a large real-world clinicogenomic research database from the United States to emulate a pragmatic randomized trial that determines the causal effect of harboring an

resultsWe included 68,145

conclusionIn this large real-world target trial emulation,

Indexed as

Gene FusionNeoplasmsAdultAgedFemaleHumansMaleMiddle AgedPrognosis

Identifiers

PMID42842841
PMCPMC13668040

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.