Evidence map›Paper›PMID 42842725›Full record

ArticleScience translational medicine2026

Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis.

Hung-Ju Chueh, Antigoni Katsikoudi, Ana Aragón-González, Chor Lai Lam, Liezel Tamon, Ashwin Jainarayanan, Devika Agarwal, Sally A Cowley, David Sims, George K Tofaris

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hung-Ju ChuehNuffield Department of Clinical Neurosciences (NDCN), University of Oxford, Oxford, UK.ORCID 0009-0002-0717-4903
Antigoni KatsikoudiNuffield Department of Clinical Neurosciences (NDCN), University of Oxford, Oxford, UK.ORCID 0009-0001-2094-3204
Ana Aragón-GonzálezNuffield Department of Clinical Neurosciences (NDCN), University of Oxford, Oxford, UK.ORCID 0000-0002-8244-0848
Chor Lai LamNuffield Department of Clinical Neurosciences (NDCN), University of Oxford, Oxford, UK.ORCID 0009-0006-6070-7093
Liezel TamonMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0003-3705-6019
Ashwin JainarayananKennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
Devika AgarwalMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.
Sally A CowleyJames and Lillian Martin Centre for Stem Cell Research, Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.ORCID 0000-0003-0297-6675
David SimsMRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-8960-8335
George K TofarisNuffield Department of Clinical Neurosciences (NDCN), University of Oxford, Oxford, UK.ORCID 0000-0002-9252-5933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microglia are the primary immune cells of the brain, but their role in Parkinson's disease is not fully understood. Chronic microglial activation is toxic to neurons, but in the early stages of pathology, microglia also exert beneficial functions. We used induced pluripotent stem cell (iPSC)-derived coculture models to investigate how human microglia respond to α-synuclein aggregates that form de novo inside human dopaminergic neurons with α-synuclein gene triplication or are triggered by fibrils. We found that microglia cleared Ser

Indexed as

alpha-SynucleinMembrane GlycoproteinsMicrogliaNeuronsPhagocytosisProtein AggregatesCoculture TechniquesDopaminergic NeuronsHumansInduced Pluripotent Stem CellsLysosomesParkinson DiseasePhosphorylationReceptors, Purinergic P2Y12Signal Transductionalpha-SynucleinGPNMB protein, humanMembrane GlycoproteinsP2RY12 protein, humanProtein AggregatesReceptors, Purinergic P2Y12

Identifiers

PMID42842725
PMCPMC7619603

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.