Evidence map›Paper›PMID 42842685›Full record

ArticleScience advances2026

Atomic structure and dynamics of the mechanosensitive channel MscL from

Taoran Xiao, Alexandra Kovinko, Chaowei Shi, Henry Sawczyc, Denis Qoraj, Carl Öster, Thiemo Sprink, Anton F Ketzel, Sascha Lange, Spyridon Kosteletos and 4 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Taoran XiaoResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-9496-6716
Alexandra KovinkoResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0009-0007-3664-0594
Chaowei ShiResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-0024-1096
Henry SawczycResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0001-9883-0405
Denis QorajResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0009-0008-6944-4175
Carl ÖsterResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-8723-4533
Thiemo SprinkCore Facility for Cryo-Electron Microscopy of the Charité-Universitätsmedizin Berlin at the Max Delbrück Center, Berlin, Germany.ORCID 0000-0002-0760-6828
Anton F KetzelResearch Unit Structural Chemistry and Computational Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0009-0001-1741-0650
Sascha LangeResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0009-0003-6941-4981
Spyridon KosteletosResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.
Han SunResearch Unit Structural Chemistry and Computational Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-1655-0838
Daniel RodererLeibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-7276-3467
Shanshuang ChenShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-2317-6589
Adam LangeResearch Unit Molecular Biophysics, Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany.ORCID 0000-0002-7534-5973

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mechanosensitive channels are central to cellular responses to membrane tension, yet the structural basis of their gating remains incompletely understood. Here, we determine the structures of wild-type and Gly22→Ser (G22S) mutants of MscL from

Indexed as

Cryoelectron MicroscopyEscherichia coliEscherichia coli ProteinsIon ChannelsMechanotransduction, CellularLiposomesMagnetic Resonance SpectroscopyModels, MolecularMutationNuclear Magnetic Resonance, BiomolecularProtein ConformationEscherichia coli ProteinsIon ChannelsLiposomesMscL protein, E coli

Identifiers

PMID42842685
PMCPMC13644787

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.