ArticleScience advances2026
Translocation-induced enhancer rewiring reveals cryptic oncogenic circuits in multiple myeloma.
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Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
27 authors.
Enrun ZhengDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.ORCID 0009-0004-4547-7336
Qinghua LiDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.ORCID 0009-0003-1955-701X
Xuelin DouPeking University Institute of Hematology, Collaborative Innovation Center of Hematology, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0001-7040-9272
Yiping CaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Chao RenAcademy of Military Medical Sciences, Beijing 100850, China.
Feiya SuoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Lin LinAcademy of Military Medical Sciences, Beijing 100850, China.ORCID 0009-0006-8310-9010
Yan ZhaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Zhiwei LiaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Yang LiuPeking University Institute of Hematology, Collaborative Innovation Center of Hematology, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0002-8471-8460
Zesen ShangDepartment of Orthopedics, Peking University Third Hospital, Beijing 100191, China.
Sudun GuanDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.ORCID 0009-0008-3119-2750
Chengying ZhangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Mengyu YangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Pengyu XiangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Yakun ChenBeijing Genome Precision Technology Co. Ltd., Beijing 100176, China.
Xinhua LiuDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou 311121, China.ORCID 0000-0002-9661-698X
Yueyun LaiPeking University Institute of Hematology, Collaborative Innovation Center of Hematology, Peking University People's Hospital, Beijing 100044, China.
Zhiqiang LiuShandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China.ORCID 0000-0002-0677-8097
Adkhamjon Odilovich AbdullayevLaboratory of Molecular Genetics, Republican Specialized Scientific and Practical Medical Center of Oncology and Radiology of Uzbekistan, Tashkent 100109, Uzbekistan.ORCID 0000-0003-2530-808X
Lin HeDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.ORCID 0000-0001-7429-8012
Xiaochen BoAcademy of Military Medical Sciences, Beijing 100850, China.ORCID 0000-0003-3490-5812
Yongfeng ShangDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.
Jichuan WangMusculoskeletal Tumor Center, Beijing Key Laboratory for Musculoskeletal Tumors, Peking University People's Hospital, Beijing 100037, China.ORCID 0009-0005-7194-0192
Jin LuPeking University Institute of Hematology, Collaborative Innovation Center of Hematology, Peking University People's Hospital, Beijing 100044, China.ORCID 0000-0001-5004-2741
Hebing ChenAcademy of Military Medical Sciences, Beijing 100850, China.ORCID 0000-0003-4102-356X
Luyang SunDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University International Cancer Institute, State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Beijing 100191, China.ORCID 0000-0003-3917-473X
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunoglobulin heavy chain (
Indexed as
Enhancer Elements, GeneticMultiple MyelomaOncogenesTranslocation, GeneticCell Line, TumorGene Expression Regulation, NeoplasticHumansImmunoglobulin Heavy ChainsPolycomb Repressive Complex 1Immunoglobulin Heavy ChainsPolycomb Repressive Complex 1
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.