Evidence map›Paper›PMID 42842675›Full record

ArticleScience advances2026

Real-time single-molecule imaging in zebrafish embryos uncovers noncanonical translation.

Maëlle Bellec, Jie Liang, Kenny Mattonet, Tatsuya Morisaki, Margaux Lay, Hans-Martin Maischein, Damien Avinens, Vincent Martinet, Delphine Muriaux, Timothy J Stasevich and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Maëlle BellecDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.ORCID 0000-0002-9029-0042
Jie LiangDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.ORCID 0000-0001-7606-9088
Kenny MattonetImaging Platform, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.ORCID 0000-0002-9705-8086
Tatsuya MorisakiDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0001-7401-4673
Margaux LayDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.ORCID 0009-0009-1255-6990
Hans-Martin MaischeinDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.
Damien AvinensInstitut de Recherche en Infectiologie de Montpellier, CNRS UMR 9004, Université de Montpellier, 1919 Route de Mende, Montpellier 34293, Cedex 5, France.
Vincent MartinetDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.
Delphine MuriauxInstitut de Recherche en Infectiologie de Montpellier, CNRS UMR 9004, Université de Montpellier, 1919 Route de Mende, Montpellier 34293, Cedex 5, France.ORCID 0000-0001-8517-9342
Timothy J StasevichDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, USA.ORCID 0000-0002-0151-6274
Jérémy DufourtInstitut de Recherche en Infectiologie de Montpellier, CNRS UMR 9004, Université de Montpellier, 1919 Route de Mende, Montpellier 34293, Cedex 5, France.ORCID 0000-0003-4043-7250
Didier Y R StainierDepartment of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Hessen 61231, Germany.ORCID 0000-0002-0382-0026

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Precise spatiotemporal control of protein synthesis is essential during embryogenesis, yet directly measuring translation kinetics in vivo remains challenging in vertebrates. In particular, it remains unclear how translation efficiency is determined for key developmental regulators and which kinetic steps limit their production. Here, we used ALFA array-based nascent chain labeling combined with lattice light-sheet microscopy to visualize

Indexed as

Embryo, NonmammalianProtein BiosynthesisSingle Molecule ImagingZebrafishZebrafish Proteins5' Untranslated RegionsAnimalsBone Morphogenetic Protein 2Gene Expression Regulation, DevelopmentalKineticsRibosomesRNA, Messenger5' Untranslated Regionsbmp2b protein, zebrafishBone Morphogenetic Protein 2RNA, MessengerZebrafish Proteins

Identifiers

PMID42842675
PMCPMC13644797

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.