Evidence map›Paper›PMID 42842665›Full record

ArticleScience advances2026

Machine learning-assisted directed evolution of plant Rubisco.

Julie L McDonald, Jiacheng Lin, Yunlong Zhao, Brian L Hie, Rosemary Birch, Mary Gehring, Bryan D Bryson, Spencer M Whitney, Matthew D Shoulders, Robert H Wilson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Julie L McDonaldDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-3715-9619
Jiacheng LinDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-1207-9364
Yunlong ZhaoDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0009-0009-0330-6885
Brian L HieSarafan ChEM-H, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-3224-8142
Rosemary BirchPlant Science Division, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.ORCID 0000-0002-3050-7406
Mary GehringDepartment of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-2280-1522
Bryan D BrysonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-1716-6712
Spencer M WhitneyPlant Science Division, Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.
Matthew D ShouldersDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0002-6511-3431
Robert H WilsonDepartment of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.ORCID 0000-0003-4168-2805

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) is foundational to life on Earth, catalyzing carbon dioxide (CO

Indexed as

Directed Molecular EvolutionMachine LearningNicotianaRibulose-Bisphosphate CarboxylaseCarbon DioxideModels, MolecularProtein EngineeringCarbon DioxideRibulose-Bisphosphate Carboxylase

Identifiers

PMID42842665
PMCPMC13644767

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.