Evidence map›Paper›PMID 42842653›Full record

ArticleScience advances2026

Endogenous retrovirus control of calbindin is essential for human early embryogenesis.

Judith Pape, Afshan McCarthy, Eduardo Serna-Morales, Borzo Gharibi, Tobias Plowman, Elias Copin, Rachael Thompson, Laura Doglio, Ruta Meleckyte-Martinez, Lyn Healy and 5 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Judith PapeRetroviral Immunology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-4225-5568
Afshan McCarthyHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Eduardo Serna-MoralesCell and Tissue Mechanobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-5906-4127
Borzo GharibiQuantitative Stem Cell Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0009-0002-9379-3929
Tobias PlowmanRetroviral Immunology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-0413-0975
Elias CopinQuantitative Stem Cell Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0001-6831-5568
Rachael ThompsonRetroviral Immunology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Laura DoglioRetroviral Immunology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.
Ruta Meleckyte-MartinezStem Cells and Organoids Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-1305-8821
Lyn HealyStem Cells and Organoids Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-7044-8789
Sara TamagnoStem Cells and Organoids Platform, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0009-0009-0386-3788
Alberto Elosegui-ArtolaCell and Tissue Mechanobiology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0003-0644-3294
Silvia D M SantosQuantitative Stem Cell Biology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-2906-7888
Kathy K NiakanHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0003-1646-4734
George KassiotisRetroviral Immunology Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.ORCID 0000-0002-8457-2633

Funding

Wellcome Trust CC2074Wellcome Trust CC2077Wellcome Trust CC2088Wellcome Trust CC2214
6 · The paper itself

Abstract

The cis-regulatory potential of human endogenous retroviruses (HERVs) that have accumulated in our genome affects diverse host processes, including embryonic development and malignancy, where HERV epigenetic control is reduced. Non-small cell lung cancer optimal growth requires cancer cell-intrinsic expression of the calcium-binding protein calbindin under the control of a

Indexed as

CalbindinsEmbryonic DevelopmentEndogenous RetrovirusesAnimalsBlastocystCellular SenescenceChromosomes, Human, Pair 8FemaleGene Expression Regulation, DevelopmentalHuman Embryonic Stem CellsHumansCalbindins

Identifiers

PMID42842653
PMCPMC13644760

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.