ArticleScience advances2026
MIMAS: An open-source microlens-array miniature microscope for accessible large-field cortical imaging in freely behaving mice.
Mian Xie, Jingyi Ma, Baoyi Zhang, Jian Lu, Hongda Yin, Yuanpeng Jiang, Yuxi Zhao, Yongjun Qian, Zengcai V Guo, Wenhao Liu and 3 more
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13 authors.
Mian XieState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.ORCID 0009-0003-4081-3882 Jingyi MaState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.ORCID 0009-0003-9090-0159 Baoyi ZhangState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.
Jian LuIDG/McGovern Institute for Brain Research, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.ORCID 0000-0003-1266-1589 Hongda YinSchool of Future Technology, Peking University, Beijing, China.
Yuanpeng JiangState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.
Yuxi ZhaoState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.
Yongjun QianSchool of Future Technology, Peking University, Beijing, China.
Zengcai V GuoIDG/McGovern Institute for Brain Research, School of Basic Medical Sciences, Tsinghua University, 100084, Beijing, China.ORCID 0000-0002-4140-7961 Wenhao LiuInnovation Photonics and Imaging Center, School of Instrumentation Science and Engineering, State Key Laboratory of Matter Behaviors in Space Environment, Frontier Science Center for Interaction between Space Environment and Matter, Harbin Institute of Technology; Harbin, China.ORCID 0009-0006-1844-5624 Qiang FuChangchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.ORCID 0000-0001-7113-0740 Changliang GuoState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.ORCID 0000-0001-6724-9060 Liangyi ChenState Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, Peking University, Beijing, China.ORCID 0000-0003-1270-7321 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Large-scale cortical dynamics during natural behavior are difficult to measure because head-mounted imaging systems must balance field of view, spatial resolution, weight, and optical complexity. Existing wide-field miniature microscopes often rely on compound or custom-corrected optical assemblies, which increase device complexity and limit accessibility for laboratories without specialized optics expertise. Here, we present the Miniature Integrated Microlens Array System (MIMAS), an open-source head-mounted fluorescence microscope that replaces conventional multi-element optics with a 4 × 5 microlens array as its sole imaging element. By combining modular subfield acquisition with computational registration and stitching, MIMAS achieves cellular-resolution imaging across an approximately 4 × 4.5 mm
Indexed as
Behavior, AnimalCerebral CortexAnimalsMiceMicroscopy, FluorescenceMiniaturizationNeurons
Identifiers
PMID42842651
PMCPMC13644769
What OpenQuestion holds
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