Evidence map›Paper›PMID 42842645›Full record

ArticleScience advances2026

SLC39-driven zinc influx orchestrates pleiotropic tumor-immune system cross-talk to establish immune suppression in colorectal cancer.

Seok June Hong, Seheum Park, Sunghoon Kim, Young Il Park, Jun Seok Lee, Mikyung Kang, Jaewoong Lee, Martin Hemberg, Sung Eun Kim, Kwoneel Kim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Seok June HongDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.ORCID 0009-0004-7364-9756
Seheum ParkSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.ORCID 0009-0001-7065-2616
Sunghoon KimSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.
Young Il ParkSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.ORCID 0009-0009-7336-6584
Jun Seok LeeDepartment of Health and Safety Convergence Science, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.ORCID 0009-0006-6830-1338
Mikyung KangSchool of Health and Environmental Science, College of Health Science, Korea University, Seoul 02841, Republic of Korea.ORCID 0000-0002-0592-1648
Jaewoong LeeSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.
Martin HembergGene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02115, USA.ORCID 0000-0001-8895-5239
Sung Eun KimSchool of Biosystems and Biomedical Sciences, College of Health Sciences, Korea University, Seoul 02841, Republic of Korea.ORCID 0000-0002-4281-5625
Kwoneel KimDepartment of Biomedical and Pharmaceutical Sciences, Kyung Hee University, Seoul, Republic of Korea.ORCID 0000-0002-4221-3421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor metabolic programs shape immune evasion; however, the mechanism by which nutrient-transport systems rewire tumor-immune cell interactions remains unknown. We integrated bulk multi-omics, single-cell transcriptomics, spatial profiling, and functional assays for colorectal cancer-associated zinc-driven immunosuppressive circuit identification. Multi-omics analysis of 258 patients revealed three solute carrier transporter-centered archetypes, with an SLC39-enriched subtype aligned with consensus molecular subtype 2-like immune-desert tumors. SLC39-mediated zinc influx activated CDX2, which engaged a distal enhancer to induce tumor cell-specific CD24 expression. CD24

Indexed as

Cation Transport ProteinsColorectal NeoplasmsZincAnimalsCD24 AntigenGene Expression Regulation, NeoplasticHumansMacrophagesPhagocytosisTumor MicroenvironmentCation Transport ProteinsCD24 AntigenZinc

Identifiers

PMID42842645
PMCPMC13644755

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.