Evidence map›Paper›PMID 42842597›Full record

ArticlePloS one2026

Predicting recovery outcomes following mild traumatic brain injury in an Australian community cohort: Results from the Concussion Recovery Study (CREST).

Jacinta Thorne, Jemma Keeves, Aleksandra K Gozt, Gill Cowen, Elizabeth Thomas, Alexander Ring, HuiJun Chih, Caerwen Beaton, Francesca Buhagiar, Amanda Jefferson and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Jacinta ThorneCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0001-5855-192X
Jemma KeevesCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.
Aleksandra K GoztPerron Institute for Neurological and Translational Science, Perth, Western Australia, Australia.
Gill CowenCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.
Elizabeth ThomasSchool of Population Health, Curtin University, Perth, Western Australia, Australia.
Alexander RingSchool of Allied Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
HuiJun ChihSchool of Population Health, Curtin University, Perth, Western Australia, Australia.
Caerwen BeatonCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0003-3141-7469
Francesca BuhagiarSchool of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia.
Amanda JeffersonCurtin Medical School, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
Melissa PapiniCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.
Glenn ArendtsDiscipline of Emergency Medicine, School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
Antonio CelenzaDiscipline of Emergency Medicine, School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
Ben SmedleyEmergency Department, Fiona Stanley Hospital, Perth, Western Australia, Australia.
Sjinene Van SchalkwykEmergency Department, Joondalup Health Campus, Perth, Western Australia, Australia.
John Charles IliffCurtin Medical School, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
Nicole GhedinaEmergency Department, St John of God Midland Public Hospital, Perth, Western Australia, Australia.
Russell YoungEmergency Department, Albany Regional Hospital, Albany, Western Australia, Australia.ORCID https://orcid.org/0009-0003-9199-752X
Monica MartonEmergency Department, Geraldton Regional Hospital, Geraldton, Western Australia, Australia.
Suzanne RobinsonCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.
Melissa LicariThe Kids Research Institute Australia, Perth, Western Australia, Australia.
Dan XuCurtin Medical School, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0001-6649-1111
Stephen HoneybulConsultant Neurosurgeon, Sir Charles Gairdner Hospital, Royal Perth Hospital and Fiona Stanley Hospital, Perth, Western Australia, Australia.
Michael ByneveltThe Neurological Intervention & Imaging Service of Western Australia, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Carmela PestellSchool of Psychological Science, The University of Western Australia, Perth, Western Australia, Australia.ORCID https://orcid.org/0000-0002-1737-7774
Daniel FatovichDiscipline of Emergency Medicine, School of Medicine, The University of Western Australia, Perth, Western Australia, Australia.
Sarah C HellewellCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.
Melinda FitzgeraldCurtin Medical Research Institute, Curtin University, Perth, Western Australia, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost people recover well following mild traumatic brain injury (mTBI). However, some experience persisting post-concussion symptoms (PPCS) for months or years. Our aims were (i) to evaluate the presence and impact of PPCS on return to functional activities over a 12-month period; and (ii) identify pre-, peri- and post-injury factors predictive of PPCS in an Australian community-based cohort at 3- and 12-months.

methodsAdults (18-65 years) with mTBI were assessed by telephone within 7 days post-injury to capture demographics, pre-injury health status, injury circumstances (including mechanism, site of head impact) and symptoms. The primary outcome measure was the presence of PPCS, measured with the Post-Concussion Symptom Scale (PCSS). Logistic regression identified predictors of PPCS at 3- and 12-months.

resultsOf 232 participants, 49.7% had PPCS at 3-months and 45.6% at 12-months. Return to work was 96.7% at 3-months and 96.9% at 12-months, despite nearly 50% reporting PPCS. Participants with a high initial symptom burden (PCSS ≥30) were six times more likely to experience PPCS at 3-months (adjusted odds ratio [aOR] 6.17, 95% CI 2.63-14.46) and three times as likely to have PPCS at 12-months (aOR 2.70, 95% CI 1.01-7.23). Acute symptoms of "feeling slow" or "nervousness" predicted PPCS at 3-months (aOR 2.97 and 2.74, respectively), but not at 12-months.

conclusionOf those who completed follow-up, nearly half had persistent symptoms at 12-months, often continuing to work despite symptoms. High initial symptom severity and acute symptoms may help clinicians identify those needing early targeted follow-up to reduce the burden of PPCS.

Indexed as

Brain ConcussionPost-Concussion SyndromeRecovery of FunctionAdolescentAdultAgedAustraliaCohort StudiesFemaleHumansMaleMiddle AgedReturn to WorkYoung Adult

Identifiers

PMID42842597
PMCPMC13645095

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.