ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026
PIEZO1 Is a Contextual Mechanosensor and Its Depletion in Scx-Lineage Cells Accelerates Structural and Functional Recovery.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Previous work has identified PIEZO1 as an important mechanosensor in homeostatic tendon, where it detects mechanical overload and regulates tissue adaptation. Here, we investigated the consequences of PIEZO1 depletion during tendon healing using a full-thickness central-third patellar tendon defect model. Unexpectedly, mechanical testing revealed accelerated functional recovery in mice with ScxCre-driven Piezo1 conditional knockout. Transmission electron microscopy and histological analyses further demonstrated accelerated structural recovery in ScxCre;Piezo1
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