ArticleDigestive diseases and sciences2026
Real-Time Computer-Aided Detection During Colonoscopy-Effects on Advanced, Diminutive, and Non-Neoplastic Lesion Detection: A Systematic Review and Meta-Analysis of Randomized Trials.
Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
BACKGROUND/
aimsComputer-aided detection (CADe) increases adenoma detection rate (ADR), but whether this improvement reflects greater detection of clinically consequential neoplasia remains uncertain. We evaluated the effects of real-time CADe on advanced, large, diminutive, and non-neoplastic lesions as distinct outcomes.
methodsWe searched PubMed, Embase, CENTRAL, ClinicalTrials.gov, and WHO ICTRP through August 27, 2026, supplemented by citation searching. Randomized controlled trials comparing real-time CADe-assisted with non-CADe colonoscopy were eligible. Patient-level risk ratios (RRs) were pooled using random-effects meta-analysis with restricted maximum likelihood estimation and Hartung-Knapp confidence intervals. Risk of bias was assessed with RoB 2 and certainty of evidence with GRADE.
resultsNinety eligible randomized trial families were identified; 64 contributed to at least one primary quantitative synthesis. CADe did not demonstrate clear evidence of increased advanced adenoma detection (25 trials; RR 1.03, 95% CI 0.97-1.10; I
conclusionsReal-time CADe increases overall ADR on average and increases non-neoplastic lesion detection, with moderate-certainty evidence suggesting increased diminutive adenoma detection. However, it did not demonstrate clear evidence of increased advanced adenoma, adenoma ≥ 10 mm, or advanced colorectal neoplasia detection. Higher ADR alone should not be assumed to represent greater detection of clinically consequential neoplasia.
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