ArticleClinical rheumatology2026
Correlation between serum IgG levels and labial gland pathological grading in patients with suspected Sjögren's syndrome: a cross-sectional analysis.
Article in Clinical rheumatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the clinical association between serum immunoglobulin G (IgG) levels and labial gland pathological grading in patients with suspected Sjögren's syndrome (SjD).
methodsThis retrospective cross-sectional study included hospitalized patients with suspected SjD who underwent labial gland biopsy between December 2023 and December 2025. Smoothing curve fitting and logistic regression models were used to assess the association between serum IgG levels and labial gland pathological grade. Sensitivity and subgroup analyses were performed to evaluate the robustness of the results.
resultsA total of 169 patients were enrolled. Compared with the low-IgG group (<15.03 g/L), the high-IgG group (
conclusionThis study provides evidence supporting a positive, linear association between serum IgG levels and labial gland pathological grade in patients with suspected SjD, suggesting that elevated IgG levels may reflect greater labial gland inflammatory involvement. KEY POINTS: This cross-sectional study identified a linear, positive association between serum IgG levels and labial gland pathological grade in patients with suspected primary Sjögren's syndrome. Patients with serum IgG levels
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