Evidence map›Paper›PMID 42842054›Full record

ArticleVirus genes2026

Innate immune transcriptomic remodeling across clinical stages of bovine leukemia virus infection.

Mohammad Mehdi Akbarin, Zahra Farjami, Gabriel Eduardo Acevedo-Jiménez, Cecilia Rodríguez Murillo, Víctor David González-Fernández, Lucero de María Ávila-De la Vega, Hugo Ramírez Álvarez

Abstract read
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In one paragraph

Article in Virus genes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mohammad Mehdi AkbarinVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico.
Zahra FarjamiVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico.
Gabriel Eduardo Acevedo-JiménezVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico.
Cecilia Rodríguez MurilloVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico.
Víctor David González-FernándezVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico.
Lucero de María Ávila-De la VegaVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico.
Hugo Ramírez ÁlvarezVirology, Genetics, and Molecular Biology Laboratory, Faculty of Higher Studies Cuautitlan, Veterinary Medicine, National Autonomous University of Mexico, Campus 4, Cuautitlan Izcalli, Mexico. ramiralh@unam.mx.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bovine leukemia virus (BLV) is an oncogenic deltaretrovirus that establishes lifelong infection in cattle and may progress from asymptomatic carriage to persistent lymphocytosis (PL) and lymphoma. Although adaptive immune alterations have been widely studied, the stage-specific transcriptional landscape of innate immunity in BLV infection remains incompletely defined. In this study, we performed a targeted innate immune transcriptomic analysis using RNA-seq data derived from 18 Holstein dairy cows selected from a screened population of 130 animals in Querétaro, Mexico. Animals were classified into three groups based on serology, proviral load, and hematological criteria: BLV-seronegative controls (n = 5), asymptomatic BLV-infected cattle (AL), and BLV-infected cattle with PL. Total peripheral blood leukocytes were subjected to RNA extraction and sequencing on the Illumina NovaSeq platform. Differential gene expression analysis was conducted using DESeq2 with significance defined as adjusted P-value (padj) < 0.05 and |log

Indexed as

Bovine leukemia virusInflammatory cytokinesInnate immunityInterferon signalingPersistent lymphocytosisRNA sequencing

Identifiers

PMID42842054

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.