Evidence map›Paper›PMID 42842043›Full record

ArticleJournal of cardiovascular translational research2026

Stacking Ensemble Learning for Diagnosing Acute Myocardial Infarction in Mice Using Plasma Raman Spectroscopy and Mass Spectrometry.

Chunyan Duan, Jing Sun, Shijun Chen, Zhengshi Wang, Lin Sun, Chengyou Jia, Xiankai Li

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of cardiovascular translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chunyan DuanDepartment of Mechanical Engineering, School of Mechanical Engineering, Tongji University, Shanghai, 201804, China.
Jing SunDepartment of Mechanical Engineering, School of Mechanical Engineering, Tongji University, Shanghai, 201804, China.
Shijun ChenDepartment of Mechanical Engineering, School of Mechanical Engineering, Tongji University, Shanghai, 201804, China.
Zhengshi WangDepartment of Thyroid and Breast, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai, 200072, China.
Lin SunMolecular Imaging Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China.
Chengyou JiaDepartment of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. jiachengyou@tongji.edu.cn.
Xiankai LiDepartment of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China. lixiankai@tongji.edu.cn.ORCID http://orcid.org/0000-0001-5416-5298

Funding

National Natural Science Foundation of China 72171170Shanghai Tenth People's Hospital YNCR2A013
6 · The paper itself

Abstract

Cardiac troponin is the reference biomarker for acute myocardial infarction (AMI) but has limited utility in the hyperacute phase. Raman spectroscopy enables rapid, label-free molecular analysis, whereas mass spectrometry offers greater molecular specificity at higher cost. Plasma from 57 coronary-ligated or Sham-operated mice underwent Raman spectroscopy and mass spectrometry. A stacking ensemble model was developed to identify AMI using Raman spectroscopy, mass spectrometry, or fused data. Under nested cross-validation, the Raman spectroscopy model yielded an area under the receiver operating characteristic curve (AUC) of 0.807 (95% CI [0.679, 0.910]). Mass spectrometry and fused models achieved 1.000 (95% CI [1.000, 1.000]), and fusion showed no detectable improvement over mass spectrometry. Cardiac troponin I demonstrated 0.714 (95% CI [0.567, 0.842]), significantly lower than mass spectrometry and fused models (Holm-adjusted p < 0.001) and numerically lower than the Raman spectroscopy model (Holm-adjusted p = 0.357). These findings require confirmation in larger human cohorts.

Indexed as

Mass SpectrometryMyocardial InfarctionSpectrum Analysis, RamanTroponin IAnimalsBiomarkersDisease Models, AnimalEnsemble LearningMaleMice, Inbred C57BLPredictive Value of TestsReproducibility of ResultsBiomarkersTroponin IAcute myocardial infarction (AMI)Mass spectrometryRaman spectroscopyStacking ensemble learning

Identifiers

PMID42842043

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.