ArticleLangenbeck's archives of surgery2026
Bile does not increase the aggressiveness of pancreatic fluid towards fibrin-based sealants in a short-term ex-vivo setting.
Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposePostoperative pancreatic fistulas are among the most serious complications of pancreatic surgery. Biliary fistulas, though usually less severe, can occur after pancreaticoduodenectomy and, when combined with pancreatic fistulas, increase morbidity and mortality. This study is the first to investigate, whether bile enhances the harmful effects of pancreatic fluid on sealant integrity in a short-term ex vivo model using a fibrin-based sealant, thereby contributing to fistula formation.
methodsWe developed and validated an improved ex-vivo setup to simulate the conditions during pancreatic surgery: the physiological incubation bio-simulator 2 (PIBS 2). A defined defect in porcine pleura was sealed with the fibrin sealant TachoSil
resultsPIBS 2 achieved stable defect closure for the electrolyte solution. Pancreatic fluid demonstrated the highest leakage rates (75%) and significantly impaired sealant stability (p < 0.001), whereas bile fluid alone showed no significant effect on sealant integrity (p = 0.63). When combined, bile and pancreatic fluid resulted in a significantly lower leakage rate compared to pancreatic fluid alone (47% vs. 75%, p = 0.041; odds ratio 3.31).
conclusionThis study replicates previous results, showing that pancreatic fluid is highly aggressive towards fibrin-based sealants. In contrast to clinical findings, the addition of bile did not significantly increase this effect in this ex-vivo model, suggesting that morbidity in patients with combined fistulas may not be primarily caused by increased aggressiveness of pancreatic fluid after its combination with bile.
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